Benjamin Brennan
Group leader and senior lecturer at the MRC-University of Glasgow Virology Research Centre, University of Glasgow
What do the latest WHO data suggest? Are there still uncertainties?
“The WHO has identified seven cases, including two laboratory-confirmed hantavirus infections and five suspected cases, with onset of illness between April 6 and 28.
Key uncertainties remain: the source of infection on board the ship has not been precisely determined (hantavirus is normally transmitted through contact with rodents, so its emergence in a cruise ship environment raises questions about routes of contamination), and the full extent of human-to-human transmission remains unclear. Previously, only limited human-to-human spread had been documented with the Andes virus. The incubation period and rates of disease progression in this outbreak warrant close monitoring.”
Why is travel history in South America relevant?
“Cases 1 and 2 traveled through South America, including Argentina, before boarding the cruise ship. This is crucial epidemiological information, as it suggests that the infection was contracted in a hantavirus-endemic region and brought on board, rather than originating from conditions on the ship. Argentina is where the Andes virus circulates, so identifying which strain of the virus is responsible is essential to assessing the current risks associated with the outbreak.
The travel histories of other passengers and crew members are still being investigated, so it remains unclear whether other individuals may have been exposed to hantavirus sources in endemic areas before boarding or during port calls. However, most passengers and crew will have been in close quarters throughout the virus's incubation period, increasing the possibility of secondary cases.”
How concerning is this?
“The WHO currently considers the risk to the global population from this event to be low, and there is no evidence of spread beyond the ship and those who had direct contact with the cases. However, the situation remains serious for those on board and their contacts: seven cases have been identified, with three deaths, one patient in critical condition, and three mild cases. The real concern is whether additional cases will emerge among the more than 140 remaining passengers and crew during this critical period. At present, appropriate priority must be given to rapid isolation, medical evacuation, and contact tracing so that affected patients receive the full and comprehensive medical treatment they need.”