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When science hits the headlines, we seek the views of expert sources who assess the news rigorously and quickly, according to the available evidence.

Spanish study claims that drinking up to 35 glasses of wine a month is associated with lower cardiovascular risk in some people

In a group of people at high cardiovascular risk, low to moderate wine consumption was associated with fewer cardiovascular events (cardiovascular death, myocardial infarction, stroke or heart failure), according to a study. The analysis uses urinary concentrations of tartaric acid, a substance found in grapes and grape derivatives, as a biomarker of wine consumption. It finds that consuming between three and 35 glasses per month was associated with fewer cardiovascular events than in people who consumed fewer than three or more than 35 glasses. The study, published in the European Heart Journal, included more than 1,200 participants from Spain's PREDIMED study with an average age of 68 years.

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Meta-analysis examines efficacy of ADHD treatments in adults

A meta-analysis published in The Lancet Psychiatry compared various pharmacological and non-pharmacological treatments for Attention Deficit Hyperactivity Disorder (ADHD) in adults. The authors found that only stimulants and atomoxetine effectively reduce symptoms after 12 weeks, but warn that the drugs are not well tolerated by everyone, that they found no evidence that they improve quality of life and that their long-term effects are unclear.

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Study estimates health and economic damages from exposure to harmful chemicals in plastics

In 2015, the human health impact of exposure to certain chemicals cost the equivalent of $1.5 trillion, says a study published in PNAS. The study estimates cases of ischaemic heart disease and stroke associated with bisphenol A (BPA) exposure; deaths of 55-64 year olds associated with di(2-ethylhexyl) phthalate (DEHP) exposure; and cognitive losses in children of mothers exposed to brominated flame retardants (PBDEs).

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More than thirty scientists warn in Science about the dangers of synthesizing 'mirror bacteria'

Thirty eight scientists from different specialties, including Craig Venter, a pioneer in the creation of artificial synthetic life, have written an article in the journal Science in which they assess the possibilities of synthesizing mirror organisms, but also warn of the risks they pose. This type of microorganisms, which would present a mirror structure to that currently found in nature, would have potential applications due to their resistance to biological degradation. However, they would also pose a danger because they would not be recognized by our defenses and could spread in ecosystems. Scientists call for more research and a broad debate, and warn that until more is known, this type of organism should not be created. 

 

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Genomic analysis clarifies the chronology of Neanderthal-modern human admixture and its genetic impact on our species

A team of researchers has analyzed more than 300 human genomes from the last 50,000 years and has concluded that most of the gene flow we received from Neanderthals is attributable to a single period, which probably occurred between 50,500 and 43,500 years ago. In addition, Neanderthal inheritance underwent rapid natural selection in subsequent generations, especially on the X chromosome, according to a study published in Science.

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'Science' magazine chooses lenacapavir to prevent HIV infection as breakthrough of the year

Science magazine has named lenacapavir as breakthrough of the year. Lenacapavir is an injectable drug that prevents HIV infection for six months with near 100% efficacy. The publication notes its potential to dramatically reduce infections in high-risk populations, but also reminds that global roll-out will depend on affordability, manufacturing agreements and a robust health infrastructure. Approval of the drug is expected by 2025. 

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Incidence of colon cancer continues to rise in young people in many high-income countries, although not in Spain

A team of researchers has analyzed data from the World Health Organization to estimate the incidence of colorectal cancer in 50 countries around the world. Their conclusions, based on records up to 2017, are that in most high-income countries its incidence continues to increase in young people (under 50 years of age). This increase, however, is not observed in Spain. The results are published in the journal The Lancet Oncology.   

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Clinical trial demonstrates efficacy of RH5.1/Matrix-M malaria vaccine in babies in Burkina Faso

The RH5.1/Matrix-M vaccine is effective and safe against malaria, according to a phase 2b clinical trial in infants in Burkina Faso published in The Lancet Infectious Diseases. Two other vaccines are already approved against malaria, a disease caused by the Plasmodium falciparum parasitebut this one acts at a different stage of the disease: when the malaria parasite is present in the blood. The other two vaccines attack the parasite when reaches the liver.

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