People who eat more ultra-processed foods have a "slightly higher" mortality rate, according to an analysis published in The BMJ. The study analysed data from more than 110,000 people followed up for over 30 years in the United States. The correlation between ultra-processed food intake and all-cause mortality was strongest for the meat, poultry and seafood group. 

Genetic forms of Alzheimer's are considered to be those in which certain variants of a gene inevitably lead to the disease over time. Until now, only rare alterations in three genes were considered as such. A group of researchers led by the Hospital de Sant Pau in Barcelona has proposed a new, much more frequent form. After analysing data from more than three thousand donated brains and clinical data from more than ten thousand patients, they found that almost all people who carry two copies of the ApoE4 variant in the ApoE gene, which was previously only considered a risk factor, also end up developing the disease.They publish the results in the journal Nature Medicine.  

Hurler syndrome is a rare and very serious disease caused by an enzyme deficiency, which results in a wide variety of signs and symptoms. Treatment with bone marrow transplantation helps to alleviate some of them, but has little effect on skeletal disorders. Now, a phase I/II trial has tested an autologous transplant of blood stem cells corrected by gene therapy in eight patients. The results, published in the journal Science Translational Medicine, suggest that the treatment is more effective and could also improve these types of disorders. 

Nirsevimab substantially reduced hospitalizations of babies from late September to late December 2023 in Galicia, according to a study published in The Lancet Infectious Diseases. This monoclonal antibody is administered to babies to prevent lower respiratory tract illness caused by respiratory syncytial virus (RSV). In Galicia, over 9 out of 10 babies received nirsevimab, which, according to the research, reduced the risk of hospitalizations for RSV-related respiratory illness by over 80%.

The Spanish Agency of Medicines and Health Products (AEMPS) has announced that the anti-obesity drug Wegovy (semaglutide) will be available, with a doctor’s prescription, starting from May. It is the same active ingredient as Ozempic, but for patients without diabetes.

Teenagers who are frequent users of electronic cigarettes have more uranium and lead in their urine than occasional users, according to a study. Those who use sweet flavored products also have higher uranium levels in their urine than those who use mint flavors. The study, published in the journal Tobacco Control, analyses data from a representative sample of adolescents aged 13 to 17 in the United States, which includes 200 exclusive users of these e-cigarettes. 

A study has analyzed how 69 of the tree species present in Europe - such as oaks, ashes or willows - will behave over this century under different climate change scenarios. In the best-case scenario, the number of species able to survive per square kilometer will be reduced by a third, according to their calculations. For the authors, who publish their results in the journal Nature Ecology & Evolution, this could have strong negative repercussions on timber production, carbon storage and biodiversity conservation.

Vitamin D enhances the response to cancer immunotherapy in mice via the gut microbiome, according to a study published in Science. The role of vitamin D in cancer immune modulation had already been studied in previous studies. Now, the authors suggest that this nutrient acts on intestinal epithelial cells, altering the composition of the microbiome and favoring a species of bacteria called Bacteroides fragilis, which regulates immunity against cancer.   

Two-thirds of biological conservation actions improve biodiversity or slow its decline, a meta-analysis claims. The study highlights the effectiveness of interventions focused on invasive species control, habitat loss reduction and restoration, and protected areas. The article, published in the journal Science, brings together the findings of 186 previous studies.   

Two independent research teams have managed to regenerate brain circuits in mice using neurons cultivated from rat stem cells. Today, both studies were published in the journal Cell. The research, in which chimeras of different species were generated, delve into how brain tissue forms and present new opportunities for restoring lost brain function due to diseases and aging.