cancer

Several recent studies had concluded that the risk of gastric cancer doubled with the use of drugs such as omeprazole – proton pump inhibitors. A new study published in The BMJ states that there is no association between prolonged use of these drugs and the risk of gastric adenocarcinoma. The research used prospective data from registries in Denmark, Finland, Iceland, Norway, and Sweden between 1994 and 2020. The study included more than 17,000 patients with gastric adenocarcinoma (other than cardia cancer) who had been exposed to these drugs for more than one year.

A higher body mass index (BMI) correlates—regardless of age at menarche—with a lower risk of breast cancer, according to a meta-analysis based on genetic data from more than 56,000 women. The study, published in Science Advances, seeks to clarify previous seemingly contradictory findings: more body fat (measured by BMI) before puberty could have a protective effect against breast cancer; however, a higher BMI is also linked to earlier menarche, which is associated with an increased risk of developing this disease. The authors indicate that the prepubertal stage is a ‘critical window’ in which adiposity has the greatest influence on future breast cancer risk.

People with colour vision deficiency and bladder cancer have lower survival rates than patients with the same cancer who have not been diagnosed with this visual condition, according to an analysis of medical records between 2004 and 2025 comparing a group of 135 people with both diagnoses and another group of 135 with bladder cancer without visual impairment. In a study published in Nature Health, the authors suggest that this difference could be due to these patients not detecting the presence of blood in their urine, which delays the seeking of medical care and cancer diagnosis.

An international team has used a type of artificial intelligence (AI) to identify the most important factors influencing cancer survival in almost every country in the world. The study provides information on policy improvements or changes that could be implemented in each nation to have the greatest impact. In general, access to radiotherapy, universal health coverage, and economic strength emerged as common and important factors. Furthermore, information for each country, including Spain, can be accessed through an online tool. The results are published in  Annals of Oncology. 

Stem cell transplants in cancer patients have achieved complete remission of HIV in a few cases in people who are also HIV-positive. However, in most cases, the donors were homozygous—with two identical copies of the gene—for a mutation in the CCR5 gene that is considered protective against the virus. A German team has now reported a new case of remission in a 60-year-old man with leukemia—called the “second Berlin patient”—in which the donor was heterozygous (only one of the two copies contained the mutation), which could broaden the alternatives. The results are published in the journal Nature.

An artificial intelligence (AI) model trained on over 400,000 mammograms and analyzed in a separate sample of over 240,000 improved cancer risk prediction in cases of dense breasts, which are more common in young women or those with a low body mass index. This is an important factor in screening, especially because it can hinder tumor detection. The results are presented as an abstract, not yet peer-reviewed, at the annual meeting of the Radiological Society of North America.

Two meta-analyses conducted by the Cochrane Collaboration confirm that vaccination against human papillomavirus (HPV) prevents cervical cancer. Both articles bring together the results of 60 clinical trials and 225 studies involving more than 130 million people worldwide. According to Cochrane's press release, the result “is strong and consistent evidence” that vaccines against this virus are effective in preventing cervical cancer and precancerous changes, especially when given to young people before they are exposed to the virus. The reviews also confirm that HPV vaccines usually cause only mild and temporary side effects, such as pain in the arm. 

The use of hormonal contraceptives is associated with a small increase in the risk of breast cancer—one additional case of cancer for every 7,752 women who use these drugs—according to a Swedish study. The risk varies depending on the type of hormones administered, and is slightly higher with the use of contraceptives containing desogestrel. The study, published in JAMA Oncology, analyses data from a national registry between 2006 and 2019, with more than two million women aged between 13 and 49.

Between 2003 and 2017, the incidence of six types of cancer—thyroid, breast, colorectal, kidney, endometrial, and leukaemia—increased in young adults in three-quarters of 42 countries included in a study published in Annals of Internal Medicine. For all of these types of cancer, except colorectal, diagnoses also increased in adults over the age of 50. The study analyses data on 13 types of cancer and notes that those with increasing incidence include some of the most obesity-related cancers, such as endometrial and kidney cancer.

Although most cancer cases are considered sporadic, some are defined as hereditary, as certain individuals carry variants in their DNA that increase their risk. A team in the United States has analysed the genetic information of more than 400,000 people and concluded that the proportion of those with known risk variants is slightly higher than 5%. This figure is higher than expected: nearly double for variants of the BRCA1 or BRCA2 genes and between 10 and 20 times higher for variants related to thyroid cancer. The results are published in the journal JAMA in research letter format.