cancer

Since 2012, a population of brown catfish in a lake between Canada and the United States has been observed to have a very high incidence of melanoma, a tumor generally associated with sun exposure. Now, a team from Vermont (USA) has discovered that, in this case, it is a transmissible cancer that spreads from fish to fish like a parasite. This finding represents the fourth known transmissible cancer in the animal kingdom and the first in any species of fish or freshwater animal; previous examples include facial tumor disease in Tasmanian devils, a venereal tumor in dogs, and leukemia-like transmissible diseases in clams, mussels, and other bivalve mollusks. The researchers published their results in Nature and emphasize that the disease poses no known risk to humans.

Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, is an aggressive tumor that is often diagnosed at advanced stages. Some people are at high risk of developing it due to a hereditary predisposition (10% of cases) or an injury. A new Phase 1 clinical trial has tested, in high-risk patients, a vaccine targeting several mutations in the KRAS gene responsible for more than 90% of these tumors. The vaccine has been shown to be safe and has stimulated specific immune responses, detectable in the blood up to two years later, in 90% of the study participants. The study is published in Cancer Discovery.

On TikTok, the vast majority (86.8 %) of videos about sunscreen promote its use, according to a content analysis of 971 of the most-viewed videos on this topic on the platform. However, the minority (6 per cent) of videos that criticise these products generate more engagement (likes, comments and shares) on TikTok, the authors warn. This misinformation stems from “small but highly influential numbers of content producers, whose shock-provoking and “sticky” content can generate considerably and disproportionately greater attention or interaction among some viewers”, they write in PLoS Digital Health.

Formaldehyde is a preservative used on human tissue; inhaling it has harmful health effects and it is considered a human carcinogen. A study published in Occupational & Environmental Medicine shows that airborne concentrations of this compound in most pathological anatomy departments of the UK’s National Health Service (NHS) are rarely monitored and regularly exceed the occupational exposure limits set by the European Union (EU): seven out of 10 departments exceeded the eight-hour maximum exposure limit set by the EU.

An international team has published the five-year follow-up results of a phase 2b clinical trial testing a personalised cancer vaccine in combination with standard immunotherapy treatment for melanoma. After this period, the probability of cancer recurrence was around 50% lower in the group of patients who received the vaccine. Furthermore, the probability of metastasis was almost 60% lower. The results are being presented at the ASCO (American Society of Clinical Oncology) conference and published in the Journal of Clinical Oncology.

Given current vaccination and cervical cancer screening campaigns, high-income countries could eliminate this disease by around 2048, according to a study published in The Lancet. However, the incidence of this cancer in low- and middle-income countries would decline by only 23% over this period if current trends continue, the article states. Elimination is defined as an incidence of fewer than four cases per 100,000 women.

A team from the Vall d'Hebron Institute of Oncology in Barcelona has published a study examining the impact of the exposome—changes in lifestyle and environmental factors—on early-onset colorectal cancer through epigenetic signatures. By analyzing methylation patterns in patients, they confirmed previously identified risk factors such as diet, educational level, and tobacco use. Additionally, they identified a significant association with picloram, a widely used herbicide. The results are published in Nature Medicine.

A team from Australia has conducted a review of various types of studies on e-cigarettes from 2017 to 2025. Their conclusion is that e-cigarettes containing nicotine are likely carcinogenic to humans and will cause an as-yet-undetermined number of cases of mouth and lung cancer. In a press release, the authors, who published their findings in the journal Carcinogenesis, state that “the conclusion is unequivocal, although it will take decades for human studies estimating the risk to accumulate.”

Glutathione is considered an antioxidant due to its ability to repair cellular damage. The body produces it naturally, but it is also sold as an antioxidant supplement. A study in mice and human tissue, published in Nature, shows that cancer cells can break it down and use it as fuel—particularly the cysteine it contains—promoting tumour growth and survival. “Depriving tumours of extracellular glutathione or inhibiting its breakdown is potentially a viable therapeutic strategy for cancer patients,” the authors state.

An artificial intelligence (AI) algorithm is capable of estimating a woman's risk of developing breast cancer in the next four years, according to a study published in The Lancet Digital Health. The tool identified women at high risk of developing breast cancer, and nearly one in ten of those who scored in the top 2% according to the algorithm were diagnosed within four years, despite having been discharged from hospital. The tool used mammograms from nearly 400,000 women and was then tested with data from nearly 96,000 women in Australia. The results were confirmed in a Swedish population of more than 4,500 women.