mental health

The Lancet Psychiatry publishes the first meta-analysis of the incidence of antidepressant treatment discontinuation symptoms that includes data from more than 20,000 patients collected from 79 randomised controlled trials and observational studies. The study sought to distinguish between symptoms directly caused by medication discontinuation and other ‘non-specific’ symptoms that may be associated with patient or professional expectations (the nocebo effect). The study concludes that one in six to seven patients will experience one or more symptoms directly caused by stopping medication, and one in 35 are likely to experience severe symptoms.  

The PsychENCODE consortium, established in 2015 and dedicated to illuminating the molecular mechanisms underlying schizophrenia, bipolar disorder, and autism spectrum disorder, presents findings based on the examination of human brains at the cellular level. The studies are published today in the journals Science, Science Translational Medicine and Science Advances.

A Finnish study involving more than 700,000 adolescents has found some risk of transmission of some mental disorders among classmates. The results are published in the journal JAMA Psychiatry. 

A review and meta-analysis of 212 studies shows that physical contact is associated with both physical and mental improvement in areas such as anxiety, depression and weight gain in newborns. The benefits were especially true if the contact was with another person, but also with items such as robots. The results are published in the journal Nature Human Behaviour.

Access to safe public spaces to meet, employment, education and public health are some of the main measures recommended to make cities more friendly to the mental health of young people and adolescents. The analysis, based on surveys of 518 people in several countries, is published in the journal Nature and is intended to serve as a guide for urban planning policies that reduce inequalities and take into account the needs of young people.

A study that has analysed more than three million pregnancies with more than 130,000 miscarriages has concluded that the use of benzodiazepines during pregnancy is associated with an increased risk of miscarriage. The results are published in the journal JAMA Psychiatry.

A dose of psilocybin—a hallucinogenic substance—administered to groups of 3 or 4 people suffering from cancer and depression may help reduce their depressive symptoms, according to a clinical trial conducted in the United States. The study involved 30 patients who also received individual and group therapeutic support. In another article, also published in the journal Cancer, the authors examine how the study participants perceived the therapy.

The largest meta-analysis to date that studies the risk of children of people with a mental disorder also suffering from some type of mental disorder during their lifetime has been published, with Spanish participation. According to the study, the risk is more than double that of the rest of the population. To explain the study and resolve any doubts that may arise, the Science Media Centre Spain organised an information session with one of the authors, psychiatrist Joaquim Raduà.

An international team, led by the Hospital Clínic-IDIBAPS in Barcelona together with King's College London (UK) and Dalhousie University (Canada), has published the largest meta-analysis to date studying the risk of children of people with mental disorders developing the same, or another type of disorder. The study included more than three million children of parents with different types of disorders and more than 20 million people as a control population. The results, published in the journal World Psychiatry, indicate that, overall, the former have a 1.5 to 3 times higher risk of developing a disorder in their lifetime. According to the authors, in the case of bipolar, depressive or anxiety disorders, the risk of their offspring suffering from some type of disorder is more than 50%.

Intimate partner violence is associated with an increased risk of depression and miscarriage, according to a systematic review of the scientific literature published since 1970. Sexual abuse in childhood is associated with an increased risk of alcohol use disorder and self-harm, says the study published in Nature Medicine. According to its authors, this analysis of 229 previous studies reveals that intimate partner violence and childhood sexual abuse have a more extensive impact on health than previously described.