mental health

Dimethyltryptamine (DMT) is responsible for the psychedelic effects of ayahuasca. According to the results of a phase IIa clinical trial published in Nature Medicine, this molecule improved depressive symptoms in adults with depression after one dose. The trial included 34 people, 17 of whom received intravenous DMT. This second group showed greater improvements in depressive symptoms than the control group. After two weeks, in the second part of the trial, DMT was administered to all participants and the antidepressant effects lasted for three months. Adverse effects were mainly pain at the injection site, nausea and transient anxiety.

High academic pressure during adolescence is linked to increased rates of depressive symptoms and self-harm, which can persist into early adulthood. This finding, published in The Lancet Child & Adolescent Health, was observed in a sample of nearly 5,000 young people born in England (UK) in 1991 and 1992. Academic pressure was measured when participants were 15 years old, mental health was assessed repeatedly between ages 16 and 22, and self-harm was tracked up to age 24. While the association with depressive symptoms was observed up to age 22, it was strongest at 16. Regarding self-harm, each one-point increase in academic pressure was associated with an 8 % higher likelihood of engaging in self-injurious behavior.

The American Psychiatric Association has unveiled the new features of the forthcoming Diagnostic and Statistical Manual of Mental Disorders (DSM) in five articles published in The American Journal of Psychiatry. Among the highlights are the proposed change of name — it will become the Diagnostic and Scientific Manual — and the intention for it to be more dynamic, incorporating biomarkers for diagnosis and integrating the socioeconomic, cultural and environmental determinants of health. According to the authors, the aim is to enable a more personalised and inclusive clinical practice, aligned with scientific rigour. The most recent update was published in 2022 with the DSM-5-TR, and specialists are currently unaware of the date of the next edition, as they reported during a briefing with journalists.

The collision between two high-speed trains in Adamuz (Córdoba) on Sunday afternoon has left at least 39 people dead and more than a hundred injured. The emotional impact of the accident affects the families of the victims, as well as the crash survivors and other train users.

The journal Science has published a review of the emerging use of artificial intelligence (AI) in mental health treatment, with examples such as conversational bots for reducing depressive symptoms. The authors defend the usefulness of this technology in the different stages of psychological care, provided that the human factor, both on the part of the clinician and the patient, is the leading factor in the approach. In this regard, they emphasise that AI cannot replace clinical judgement. The distinctive characteristics of psychological care, such as the disclosure of personal information by vulnerable individuals, also necessitate regulatory frameworks that ensure ‘the ethical and effective implementation of AI technologies’.

Physical exercise of any kind shows similar benefits to psychological therapy for the treatment of depression in adults. This is one of the conclusions of a new systematic review by the Cochrane Collaboration based on data from almost 5,000 people, which is the latest update of a review first published in 2008. With regard to antidepressants, the research shows a similar effect, but the evidence is somewhat more limited. The authors point to the lack of robustness in terms of long-term treatment with physical exercise. 

One in five people in Spain suffers from unwanted loneliness, but what exactly is it? What consequences can it have and who suffers from it most? Is it appropriate and realistic to talk about an epidemic of loneliness? What are the causes and possible solutions? What role do social networks play? We answer these and other questions about a central problem in our societies.

A study published in the journal Scientific Reports reveals an increase in simplicity, negativity, and stress-related words in pop song lyrics in the United States over the last few decades. The authors also conclude that this phenomenon was attenuated in times of social crisis, such as the COVID-19 pandemic, which ‘highlights the role of music in both shaping and reflecting moods.’ The data included more than 20,000 songs from the US charts between 1973 and 2023. 

A meta-analysis published in The Lancet Psychiatry journal concludes that the most effective way to discontinue antidepressant treatment in people with remitting depression is to gradually reduce the dose in combination with psychological therapy. Furthermore, this strategy proved to be just as effective in preventing relapses into depression as continuing medication. The study was based on data from more than 17,000 adults with depression and anxiety in remission, although the evidence for the latter disorder was not as robust. 

A study published in Scientific Reports concludes that adults who use Instagram very frequently overestimate their ‘addictive’ use, which complicates self-control and increases feelings of guilt. According to the research, excessive use, in most cases, is not an addiction but a habit. The study was conducted on more than 1,000 Americans and suggests that the fact that many think they have an ‘addiction’ may be related to the media's frequent use of this term when talking about social media.