Institute of Health Research-Fundación Jiménez Díaz
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SMC participants
Researcher at the Department of Pharmacology, the Faculty of Medicine of the Universidad Autónoma de Madrid and at the Nephrology and Hypertension Laboratory of the Instituto de Investigación Sanitaria-Fundación Jiménez Díaz in Madrid
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Researchers have modified a bacterium to colonise the gut microbiota and treat kidney stones. They genetically engineered Phocaeicola vulgatus to make it able to break down oxalate molecules, a cause of recurrent kidney stones, and consume a specific nutrient called porphyrin. In mice and in preclinical trials in healthy people, this reduces oxalate levels, the authors report in the journal Science.