Matteo Cerri
Associate Professor of Physiology at the Department of Biomedical and Neuromotor Sciences, University of Bologna (Italy)
It is a significant advancement since it is the first to use a non-invasive technology. This will open new exciting fields of research. The experiments are well conceived, testing both in a hibernator (mouse) and a non-hibernator (rat).
It fits well with what we know about the neural control of torpor. A few technical details also open interesting new questions.
The implication is significant since i) the paper shows the use of a non-invasive tech; ii) it offers a way to maintain a torpor-like state for 24h automatically. This last part complements the main findings because it will allow automated control of physiological states.
The main limitation is the technology's very modest effect on rats (although present). So, there is still work to do in that compartment. We may be headed towards a composite system that can merge Ultrasound stimulation with pharmaceuticals to reach for a significant hypometabolism in humans. The limited, although significant, effects on rats also suggest there is still work to do to have suitable human applications. Considering the degree of hypometabolism reached, I believe this technology will be helpful in specific conditions where even modest hypothermia can be already very beneficial, more than for interplanetary travels.