Reacción a "Reactions: epigenetic editing technique lowers cholesterol in mice without altering DNA"

This is fantastic quality work, done by a group that I know well and that is very strong and pioneering in this field of epigenetic editing. 

This study has achieved results similar to those achieved with gene editing (by the company Verve Therapeutics, with CRISPR-based base editors). I also find it very interesting at a conceptual level. In this case, a gene is effectively deactivated without changing a single base in the genome. It is very interesting to see that these changes in gene expression are not only maintained over a long period of time, but are 'inherited' after liver regeneration. 

This is a very new advanced therapy modality. As always in these cases, all types of toxicity and longer-term efficacy will need to be closely monitored, but the study looks very promising.