Roderic Guigó
Coordinator of the Bioinformatics and Genomics Program at the Centre for Genomic Regulation (CRG) in Barcelona
This is an interesting article. First, genomic data is heavily biased towards populations of European origin because biological samples are mostly obtained from individuals of this ancestry (70-80%). This limits the possibility of applying the advances of genomic medicine universally, since the same mutation can have a different effect depending on the genetic environment, which varies among different human populations.
On the other hand, the article shows that genomics can also be a valuable tool in the study of history. In this specific case, it greatly helps to clarify the human colonization of the American continent.
Overall, it is not surprising to find new genomic variants that were not present in the sequences deposited in public databases, since, as I mentioned, these sequences mostly correspond to genomes of individuals of European descent.