Reacción a "Study reviews adverse reaction reports for semaglutide and suicide"

I am concerned that these analyses combine and conflate on-target effects of GLP-1R agonists with the broader consequences of weight loss.  There are biological effects of the mechanism of action of these drugs.  And there is the wider impact of losing as much as 20% of one’s bodyweight, as has been seen in trials of these drugs.  This is a life-changing intervention that will have largely positive consequences for many.  But for others, the impact of losing a large amount of weight could have negative emotional consequences.  If an individual thinks that losing weight is the key to happiness, but losing weight does not bring happiness, could this lead to depression and suicidal ideation?  And if it did, would we say that GLP-1R agonists caused suicidal thoughts?  While any mechanism that increases suicide risk demands action, these two potential causal pathways require different management.  We need to understand whether these results represent a specific side-effect of these drugs, or an uncommon but tragic consequence of some individuals’ weight loss journey.