Marina Pollán
Cancer epidemiologist and Director General of the Carlos III Health Institute
I believe that the most noteworthy aspect of this article is the effort to provide data for everyone on the leading cancer in women, focusing not only on indicators such as incidence and mortality, but also addressing the burden that this disease represents in terms of years of life lost and years of life lived with disability. The methods used have been developed by GBD and involve a series of assumptions and generalisations that may not be entirely appropriate for particular cases. As an example, the estimated number of breast cancer cases for Spain in 2023 according to this article is 29,400, with an uncertainty interval ranging from 24,600 to 34,400. The SIEC (Spanish Cancer Information System), based on data from existing tumour registries and the methodology developed by the IARC, provides an estimate for the same year of 35,540. In other words, it appears that GBD is underestimating the number of cases in our country. With regard to mortality, the information available in Spain (this is not an estimate, as we have actual data for the whole country) shows that in 2023, 6,405 women died from this cause, a figure clearly lower than that provided in this study (7,890). Despite this variability, I believe the article is important for the reasons mentioned above: it highlights the burden of disease of this tumour, which is a public health problem worldwide, the different life expectancy of women with this disease in higher- and lower-income countries (incidence is higher in countries with a high economic level and mortality is lower), and it also shows the role of some of the modifiable risk factors.