A study shows that carriers of nicotine-related genetic variants smoked fewer cigarettes
Sequencing the genomes of nearly 38,000 smokers in Mexico revealed that variants in a nicotine receptor gene were associated with a lower likelihood of heavy smoking, according to a study published in Nature Communications. The variant occurs in the CHRNB3 gene, which encodes the β3 subunit that binds nicotine and mediates its rewarding effects in the brain. Compared with individuals carrying the more common version of the gene, those with one or two copies of the identified variant smoked 21% and 78% fewer cigarettes, respectively. The findings were validated in populations of Asian and European ancestry.
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