MD Anderson Cancer Center Madrid
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Head of the Medical Oncology and Breast Unit and Head of the Obesity-Breast Cancer Unit
A higher body mass index (BMI) correlates—regardless of age at menarche—with a lower risk of breast cancer, according to a meta-analysis based on genetic data from more than 56,000 women. The study, published in Science Advances, seeks to clarify previous seemingly contradictory findings: more body fat (measured by BMI) before puberty could have a protective effect against breast cancer; however, a higher BMI is also linked to earlier menarche, which is associated with an increased risk of developing this disease. The authors indicate that the prepubertal stage is a ‘critical window’ in which adiposity has the greatest influence on future breast cancer risk.