Reacción a "A study in mice suggests that faecal microbiota transplantation could have unexpected effects on other areas of the digestive system"

The study aims to assess the impact of faecal microbiota transplantation (FMT) on the microbial ecosystem of the gastrointestinal tract, with a particular focus on the changes induced in the small intestine and their possible consequences on host homeostasis.

For this purpose, the authors used murine models and, in the human case, organoids derived from duodenal biopsies. However, it is important to note that the human study had a very small sample size and a follow-up restricted to only one month. Both the experimental design, the small sample size and the short duration of follow-up in humans are relevant methodological limitations that should be taken into account when interpreting the results.

The results of the study indicate that TMF causes alterations in the composition and function of the gut microbiota, affecting host metabolism as well as intestinal and liver transcriptomic profiles. The authors conclude that TMF induces modifications in the intestinal bacterial ecosystem that could have adverse consequences for host health and metabolism.

Despite these findings, currently available scientific evidence considers TMF a safe procedure, especially in the short term, provided it is performed under controlled conditions and complies with quality, safety and legal standards. In addition, multiple clinical trials have demonstrated its high efficacy and safety in the treatment of recurrent Clostridioides difficile infection.

While this study suggests that TMF may induce disruptions in host homeostasis through alterations of the microbial ecosystem, its methodological limitations prevent drawing firm conclusions. Nevertheless, this work highlights the need for further research on the effects of TMF, particularly with regard to its impact on the small intestine and its applicability in other clinical settings.