Autor/es reacciones

Denis Headon

Group Leader and Senior Research Fellow, The Roslin Institute, University of Edinburgh

With a long-term goal of advancing the de-extinction of the mammoth, the team have managed to alter several mouse genes in one step. They chose these gene alterations based largely on things that we know about mice, rather than what we know about mammoths. This approach produced very shaggy mice with a coat that resembles that of the woolly mammoth remains we find today. While the mice have a striking golden coat, they are otherwise healthy, indicating that the method used is not harmful. Certainly this is an advance in speeding up the rate of genetic modification towards the many changes that distinguish one species from another, though it’s not clear that these changes alone would alter a relatively hairless elephant into a woolly animal. Further work on either synthesising or understanding the mammoth genome would also be required to go beyond these superficial characteristics to generate an animal that would, for example, have the right behaviour to live in Arctic conditions. This paper reports an important advance not only for de-extinction but for animal breeding in general.

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