Reacción a "Reactions: The lineage of the so-called 'swine flu' has passed from humans to pigs almost 400 times since 2009"

This study is a great example of the importance of reverse zoonoses, that is, the transmission of pathogens from humans to animals (in this case, pigs).

Historically, little attention has been paid to this type of animal-human contagion, largely due to our anthropocentric vision of health, in which we tend to consider humans as victims of contagion, but never as its origin.

The H1N1 pandemic influenza virus is a zoonotic virus that arose on a pig farm in Mexico from a combination of genetic material from avian, swine and human influenza viruses. The virus managed to jump from pigs to humans and then fully adapt to its new host, effectively transmitting from person to person around the world. Just one month after the pandemic H1N1 virus had reached a worldwide distribution, the first cases of human-to-animal transmission were detected. The first outbreak occurred on a pig farm in Canada and since then the virus has jumped from humans to pigs hundreds of times, as confirmed by this study.

The main risk of these reverse zoonoses is that the animal host ends up becoming a reservoir of the pathogen in question. In other words, the virus adapts to the pig and continues to evolve in it, so that it can accumulate mutations that end up giving rise to a more dangerous virus, either because the seasonal flu human vaccines are less effective against it or because the Pre-existing human immunity against the parent strain does not protect against variants originating in pigs.

It is well known that the pig is a key species in the emergence of zoonotic influenza viruses. In fact, it is considered the main “shaker species”, since it is susceptible to swine, human and bird flu viruses. If a swine cell is infected at the same time by influenza viruses of various origins, a rearrangement of genetic segments may occur, giving rise to a new subtype capable of infecting various species. This is what happened with the H1N1 strain in 2009 and what could happen again at any time, especially in the current situation in which we are suffering from the largest avian flu epidemic in history, caused by the H5N1 subtype, which we know is it can also infect the pig.

The pig has been the species most affected by these reverse transmissions of the H1N1 virus, but it has not been the only one. Human-animal contagion has been confirmed in other livestock species such as turkey, in pets such as dogs, cats, and ferrets, in zoo animals, and in mink on fur farms.

It is likely that all these species remind you of something. Indeed, all of them, except the turkeys, have recently been infected with another pandemic virus: SARS-CoV-2. In fact, there are many similarities between the two viruses, especially in the spectrum of species that they can infect and in the risk of the appearance of animal reservoirs that greatly complicate the control of the disease at a global level. Both examples remind us that zoonoses are transmitted in two directions and that ignoring this fact can have very serious consequences for our health and that of the planet. To fight against these viruses, it is essential that animal health and public health professionals work in coordination, accepting that everything is connected and that health will be global or it will not be.