Spanish National Research Council (CSIC)

EMA’s human medicines committee has recommended not authorising the marketing of Kisunla (donanemab), a drug intended for the treatment of early-stage Alzheimer's disease. The committee considered that the benefits of this drug were not great enough to outweigh the risk of potentially fatal events. In recent years, several patients have died due to microbleeds in the brain.

A team in the US has tested the efficacy of baloxavir, an antiviral already on the market for treating common flu, against avian influenza in mice. The results, published in the journal Nature Microbiology, show that it is more effective than the currently recommended oseltamivir (Tamiflu) except when the infection is via the mouth, in which case it is equally effective. According to the authors, baloxavir ‘could be considered for the potential treatment of serious H5N1 virus infections in humans’.

23% of people infected with SARS-CoV-2 between 2021 and 2023 developed long covid and more than half of them had persistent symptoms for two years. These are the main conclusions of a study led by ISGlobal that followed more than 2,700 people in Catalonia. The results are published in the journal BMC Medicine.

Colossal Biosciences has announced the creation of genetically modified mice with characteristics reminiscent of the fur of extinct mammoths, such as fur colour, texture and thickness. The non-peer-reviewed results were shared today in the BioRXiv prepublication repository.

An article reviews evidence on the accumulation of microplastics in human brain tissue recently published in Nature Medicine. The authors highlight practical measures to reduce exposure, noting that switching from bottled water to filtered tap water could reduce microplastic intake from 90,000 to 4,000 particles per year. The paper is a commentary in Brain Medicine. 

According to a modelling study published in Nature Cities, the frequency of some types of fires in cities is expected to increase in the coming decades as a result of climate change. This increase would be seen in vehicle fires and in those that occur outdoors. The conclusions are based on data from more than 2,800 cities in 20 countries and could be useful for future urban planning and emergency response strategies.

Research has analyzed how extreme heat influences the biological age of elderly populations, specifically in the United States. The study, published in Science Advances, used blood samples from more than 3,600 adults with an average age of 68 collected between 2010 and 2016. The team compared epigenetic aging trends with the number of days of extreme heat in the participants' places of residence. The models showed that more days of heat or long-term heat — over a period of one to six years — increased the biological age of the participants by more than two years.

The red colour of Mars corresponds to a type of ferrihydrite that is the dominant form of iron oxide in Martian dust, although previous studies have attributed it to anhydrous haematite. The persistence of ferrihydrite, whose formation requires water, suggests that it formed during a cold, wet period, followed by a transition to the planet's current arid environment. The result, based on ESA and NASA space data and new laboratory experiments, is published in Nature Communications.

One study suggests that conservation efforts are concentrated around a small number of charismatic species, such as elephants. However, there are undervalued species, such as fungi, plants and invertebrates, that are critical to the functioning of ecosystems. The research, published in the journal PNAS, analysed more than 14,000 conservation projects spanning a 25-year period - from 1992 to 2016. Of the nearly $2 billion allocated by the projects, 83% went to vertebrates. Plants and invertebrates each received 6.6% of the funding, while fungi and algae received less than 0.2%.

An international team has analyzed data from nearly half a million people to analyze the influence of genes or environment on mortality, age-related diseases and aging. Although the relationship may vary according to the type of disease, their conclusions are that the environment -especially socioeconomic conditions, smoking habits and physical exercise- has a much greater influence than genetics in all the aspects studied. Among other data, environment explains 17 % of the variation in mortality risk, while genetics is limited to 2 %. The results are published in the journal Nature Medicine.