Spanish National Research Council (CSIC)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive loss of motor neurons. An international team has discovered evidence that ALS may have an autoimmune component, meaning that the immune system mistakenly attacks healthy cells, a hypothesis that had been considered by the scientific community. The study shows that inflammatory immune cells—called CD4+ T cells—attack certain proteins that are part of the nervous system in people with ALS. ‘These findings highlight the potential of therapeutic strategies aimed at improving regulatory T cells,’ the authors note in the research, published in Nature.

The North American strain of the H5N1 avian influenza virus has been shown to be capable of causing outbreaks in mammals such as cows, something not seen elsewhere in the world, including Europe. An international team has identified and tested two mutations in ferrets that may explain improved adaptation and greater virulence. According to the authors, who published the results in the journal Science Advances, the finding "highlights the urgent need for strengthened surveillance and targeted interventions.

Most rare diseases are caused by mutations in DNA, but the same gene can mutate in different ways, which complicates treatment. Now, a team from the CRG in Barcelona has shown that an already approved drug is capable of stabilising almost all mutated versions of a human protein—specifically, the vasopressin V2 receptor, which is linked to a rare disease called nephrogenic diabetes insipidus. According to the researchers, who published their findings in Nature Structural & Molecular Biology, the study is the first proof of concept demonstrating that a drug can act as a ‘near-universal’ treatment, which could accelerate the development of therapies.

Avian influenza has returned to Spain this summer. In addition to a few cases in wild birds, since 18 July there have been several outbreaks in poultry in different autonomous communities, causing the country to lose its disease-free status. To answer questions about the situation, its possible causes, evolution and consequences, SMC Spain organised an information session with researchers Inmaculada Casas, Ursula Höfle and Elisa Pérez Ramírez.

The Planetary Health Diet promotes environmentally sustainable consumption, based, among other things, on increasing vegetable intake and reducing dairy and red meat consumption. Previous studies had found an association with better human health, although there were some conflicting results. Now, a study combining two cohorts of more than 150,000 people and a meta-analysis of 37 studies involving more than three million volunteers reinforces this association, finding that greater adherence to the diet is associated with lower all-cause mortality. The results are published in the journal Science Advances.

Climate change has made the hot, dry and windy weather conditions that spread fires across the Iberian Peninsula 40 times more frequent and 30% more intense than in the pre-industrial climate, according to a rapid study by World Weather Attribution. The ten-day heatwave was also 200 times more likely and 3°C hotter due to climate change. The study, which analysed weather observations rather than climate models, warns that fires in Europe are overwhelming firefighting resources and highlights the importance of controlling vegetation in affected areas.

An international team has analysed gender representation in more than 1,000 clinical trials on cardiovascular disease between 2017 and 2023, involving more than one million people. Although female participation has increased, especially in areas such as obesity and heart failure, women continue to be underrepresented overall compared to men. The results, presented at the European Society of Cardiology (ESC) Congress held in Madrid from 29 August to 1 September, are published in JAMA Network Open.

Amino acids are the building blocks of proteins. These are known as the building blocks of life, but they cannot replicate themselves. To do so, they need the instructions provided by RNA. How this relationship began is still a mystery. Now, a British team has shown how it could have started from relatively simple conditions. According to the researchers, who published their findings in the journal Nature, ‘understanding the origin of protein synthesis is fundamental to understanding where life comes from.’

A US team has analyzed the evolution of the global population exposed to forest fires between 2002 and 2021. The study indicates that the number of people exposed has increased by 40%, despite a 26% reduction in the area burned. This is mainly due to the increase in the population living in urban-forest interfaces. 85% of exposures occurred in Africa, even though forest fire disasters in North America, Europe, and Oceania have received most of the attention, notes the study, which is published in the journal Science.  

After 10 days of meetings and beyond the deadline, representatives from more than 180 countries gathered at the UN headquarters in Geneva (Switzerland) have failed to agree on a global treaty against plastic pollution, the first legally binding one. This negotiation was, in principle, the last chance to reach an agreement, after the last meeting in Busan (South Korea) also ended without a treaty in December, two and a half years after negotiations began.