Spanish National Research Council (CSIC)

An international team has used the CRISPR gene-editing tool to modify a key gene for the replication of the classical swine fever virus in pigs. The experiment, conducted on four animals, showed complete protection against the disease. According to the researchers, this breakthrough could serve as an additional method for controlling this type of virus, which entails significant economic and animal welfare costs. The results are published in the journal Trends in Biotechnology. 

Some ecosystems are able to adapt to moderate droughts, even if they last for several years. However, in scrublands and grasslands, when the phenomenon is extreme and prolonged, their capacity to store carbon plummets. This is the main conclusion of an international study that has assessed the effects of the duration and severity of droughts on the productivity of 74 grassland and pasture ecosystems on six continents. According to the authors, the most vulnerable areas are arid and semi-arid regions, such as those in the Mediterranean region and the southwestern United States. The study, published in Science, involves CREAF, CSIC and IICG-URJC, among other centres.

In 2050, the total volume of waste electrical and electronic equipment in Europe will reach between 12.5 and 19 million tonnes, compared to 10.7 million tonnes – around 20 kilograms per person – in 2022, according to the report 2050 Critical Raw Materials Outlook for Waste Electrical and Electronic Equipment. Of this volume, only 54% was collected and treated correctly in 2022. Furthermore, of the one million metric tonnes of critical raw materials such as copper, aluminium and silicon present in this waste, less than half was successfully recovered, according to the report's estimates.

The Royal Swedish Academy of Sciences has awarded the 2025 Nobel Prize in Chemistry to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for the development of molecular structures with large spaces through which gases and other chemicals can flow. These structures, called metal-organic frameworks, can be used to extract water from desert air, capture carbon dioxide, store toxic gases, or catalyze chemical reactions.

The Royal Swedish Academy of Sciences has awarded the 2025 Nobel Prize in Physics to John Clarke, Michel H. Devoret, and John M. Martinis, who demonstrated both the quantum tunnelling effect and quantised energy levels in a system small enough to fit in the palm of your hand. These advances have served to develop the next generation of quantum technology, including quantum cryptography, quantum computers and quantum sensors.

The Karolinska Institute has awarded the Nobel Prize in Medicine or Physiology to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for describing how the immune system is regulated so as not to harm us. His groundbreaking discoveries on peripheral immune tolerance have spurred the development of new treatments for cancer and autoimmune diseases.

The very functioning of the cell itself or stresses such as those caused by sun exposure can cause breaks in our DNA, which must be repaired. A study developed by the CNIO has completed a catalog of how each of our genes affects the repair of some of these breaks and how they influence the resulting "scars." The catalog, which they have called the "human repairome," will be openly available. According to the researchers, whose work is published in Science, it will have "implications for human health, including the biology and treatment of cancer, as well as for efforts toward total control of CRISPR-Cas gene-editing technologies".

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive loss of motor neurons. An international team has discovered evidence that ALS may have an autoimmune component, meaning that the immune system mistakenly attacks healthy cells, a hypothesis that had been considered by the scientific community. The study shows that inflammatory immune cells—called CD4+ T cells—attack certain proteins that are part of the nervous system in people with ALS. ‘These findings highlight the potential of therapeutic strategies aimed at improving regulatory T cells,’ the authors note in the research, published in Nature.

The North American strain of the H5N1 avian influenza virus has been shown to be capable of causing outbreaks in mammals such as cows, something not seen elsewhere in the world, including Europe. An international team has identified and tested two mutations in ferrets that may explain improved adaptation and greater virulence. According to the authors, who published the results in the journal Science Advances, the finding "highlights the urgent need for strengthened surveillance and targeted interventions.

Most rare diseases are caused by mutations in DNA, but the same gene can mutate in different ways, which complicates treatment. Now, a team from the CRG in Barcelona has shown that an already approved drug is capable of stabilising almost all mutated versions of a human protein—specifically, the vasopressin V2 receptor, which is linked to a rare disease called nephrogenic diabetes insipidus. According to the researchers, who published their findings in Nature Structural & Molecular Biology, the study is the first proof of concept demonstrating that a drug can act as a ‘near-universal’ treatment, which could accelerate the development of therapies.