ageing

A clinical trial (COSMOS) involving 958 healthy adults with an average age of 70 tested the ability of a multivitamin supplement, together with cocoa extract, to slow ageing. The results, published in Nature Medicine, show that the supplement slightly slowed two of the five biological markers of ageing measured after two years of daily use. The two markers affected were PCPhenoAge and PCGrimAge, whose rate of increase was reduced by 2.6 months and 1.4 months respectively. The slowing effect was greater among participants who initially showed more accelerated ageing. Cocoa showed no effect.

Genetics accounts for approximately 55% of the variability of human lifespan, which is more than double previous estimates, according to research published in the journal Science. The analysis is based on mathematical models and data from twin registries in Denmark, Sweden, and the United States. According to the authors, this high heritability is similar to that of most other complex human traits and to the influence of genetics on the life expectancy of other species.

An international team has analysed data from more than 700 mammal populations in zoos since 1970 and concludes that there has been an ageing of the animals and a decline in females of reproductive age. According to the authors, this jeopardises the role of zoos in conserving endangered wildlife species and promoting global biodiversity. The findings are published in the journal PNAS.

Consuming up to four cups of coffee a day is associated with an increase in telomere length in people with severe mental disorders, such as schizophrenia or bipolar disorder. Telomere length is an indicator of cellular ageing and is shorter in people with these disorders, although the causes are not clearly understood. According to the study, published in BMJ Mental Health, the effect shown is comparable to ‘a biological age five years younger’ in coffee drinkers. 

An international team, including Spanish researchers, has analyzed data from more than 86,000 people aged 51 to 90 from 27 European countries and concluded that multilingualism—the habit of speaking more than one language—is associated with a reduced risk of accelerated aging. According to the authors, who published their findings in the journal Nature Aging, “these findings could inform educational and public health policies aimed at promoting cognitive resilience and functional capacity in older populations.”

The decline in egg quality has been considered the main cause of declining fertility with age. A new study published in Science shows that the cells and tissues surrounding the oocytes within the human ovary also play a crucial role. They identified 11 types of cells in the ovaries, including nervous system cells, that influence follicle development. In addition, they have discovered that oocytes are grouped into “pockets” within the ovary and that the density within these pockets declines over the years. 

Maria Branyas was considered the oldest person in the world when she died in 2024 at the age of 117. An international team led by the Cancer Epigenetics group at the Josep Carreras Leukaemia Research Institute and the University of Barcelona has analysed her molecular profile, including her genome, metabolome, microbiome and epigenome. "Our results have helped us identify factors that could help many older people live longer, healthier lives," say the researchers, whose work is published in the journal Cell Reports Medicine.

An international team has analysed data from more than 160,000 people in 40 different countries, including Spain, to study differences in the speed of ageing between regions and the factors responsible. According to the results, European countries show healthier ageing, while low-income countries are associated with accelerated ageing. Protective factors include physical factors such as air quality; social factors such as socioeconomic and gender equality; and sociopolitical factors such as freedom of political parties and democratic elections. The study is published in the journal Nature Medicine.

Aging is associated with an increase in chronic inflammation, a phenomenon known as inflammaging that is related to different diseases and that was considered universal. Now, an international team has analyzed data on 19 inflammation-associated proteins in four different populations: two industrialized (from Italy and Singapore) and two non-industrialized (the Tsimane population of the Bolivian Amazon and the Orang Asli population of Malaysia). The results show that, at least according to this form of measurement, in the non-industrialized populations there is no increase in inflammation with age, which questions whether this is a biological imperative and indicates that it would depend on lifestyles and social and cultural factors. The paper is published in letter format in Nature Aging. 

Several studies have suggested that taurine concentrations in the blood decrease with age and that supplementation with this amino acid could delay ageing. Now, a study carried out in the USA with Spanish participation, including data from humans, monkeys and mice, shows that this decline is not systematic and that it depends more on individual factors than on ageing, so taurine is not a reliable marker of ageing. The results are published in the journal Science.