An Australian team has conducted a study involving mice and humans that suggests that vaccine boosters would be more effective if administered in the same arm as the previous dose, at least in the short term. However, other recent research has pointed in the opposite direction. The results are published in the journal Cell.
If immunisation rates continue to decline over an extended period, measles and even other eradicated diseases—such as rubella and polio—could re-emerge in the United States at endemic levels, according to a new study published today in the journal JAMA.
In mice, a therapy based on editing regulatory T-cells can suppress an immune reaction against gluten, according to a study in Science Translational Medicine. Studies in animals with coeliac disease would be needed to assess the efficacy of this cell therapy in restoring gluten tolerance, the authors say.
A CNIC research team has identified a population of skin neutrophils that reinforce the physical protection of the tissue against infection. These immune cells are known for their microbicidal role, and the study published in Nature reveals that they also produce an extracellular matrix that reinforces the physical barrier of the skin.
According to a new study published in Science, a machine learning-based artificial intelligence (AI) system - called Mal-ID - can decipher an individual's history of infections and diseases in the immune system. The authors say this provides a powerful tool with the potential to accurately diagnose autoimmune disorders, viral infections and vaccine responses.
A team of researchers from the USA has analyzed the B lymphocytes of seven healthy people in whom no exposure to H5 influenza viruses, such as the avian flu virus, had been documented. The results show that they present antibodies capable of recognizing this type of virus, which, according to the authors, could represent “a first line of defense” in the event of a pandemic. The results are published in the journal Science Immunology.
A study in mice reveals that immune cells in the brain 'engulf' microplastics, forming clumps that can cause brain clots. The findings, published in the journal Science Advances, highlight how microplastics can indirectly damage the brain by disrupting blood flow, rather than directly infiltrating brain tissue cells.
Inflammation is all the rage. In fact, anti-inflammatory diets that claim to fight it. This is attested to by best-selling books and influencers, ready to give us the latest tips on how to lose weight, or rather, how to reduce inflammation. But what's the truth in all this, and what does inflammation have to do with being overweight?
Research in mice shows that the gut microbiota of pregnant mice influences the development of stem cells in their offspring. Changes in the bacterium Akkermansia muciniphila in the maternal microbiota alter the proliferation of intestinal and neural cells in the offspring, according to the study published in Cell Stem Cell.
Antimicrobial resistance caused around 5 million deaths worldwide in 2019. The use of vaccines has the potential to reduce these deaths - 515,000 fewer deaths per year - according to a report published by the WHO. The work focused on 24 pathogens and 44 vaccines, licensed by regulatory agencies, in clinical development or in development. By counting existing vaccines alone, antibiotic use could be reduced by 142 million daily doses per year.