microbiology

A study published today in Nature with the participation of the CNIO points to the bacterial toxin colibactin, produced by some strains of Escherichia coli, as a possible culprit in the increase in early-onset colorectal cancer. The study shows that exposure to the toxin during early childhood leaves a genetic signature in colon cells and demonstrates a substantial increase in these mutations in cases of colorectal cancer in people under 50.

A team from Canada and the United States has found a candidate to form part of a new class of antibiotics, lariocidin. This could be effective against multi-resistant bacteria. The finding is published in the journal Nature.

A CNIC research team has identified a population of skin neutrophils that reinforce the physical protection of the tissue against infection. These immune cells are known for their microbicidal role, and the study published in Nature reveals that they also produce an extracellular matrix that reinforces the physical barrier of the skin.

A synthetic microbiome therapy, tested on mice, protects against the severe symptoms of a difficult-to-treat and potentially fatal intestinal infection in humans: Clostridioides difficile. Although inspired by the idea of human faecal transplants, the new approach does not require faecal matter. Instead, it uses fewer, but more precise, bacterial strains. The study is published in the journal Cell Host & Microbe.

Thirty eight scientists from different specialties, including Craig Venter, a pioneer in the creation of artificial synthetic life, have written an article in the journal Science in which they assess the possibilities of synthesizing mirror organisms, but also warn of the risks they pose. This type of microorganisms, which would present a mirror structure to that currently found in nature, would have potential applications due to their resistance to biological degradation. However, they would also pose a danger because they would not be recognized by our defenses and could spread in ecosystems. Scientists call for more research and a broad debate, and warn that until more is known, this type of organism should not be created. 

Many diseases related to bacteria, such as inflammatory bowel disease or colorectal cancer, are associated with an overgrowth of gut bacteria considered 'bad'. However, a study published in the journal Cell suggests that changes in microbial load, rather than the disease itself, could be the driving factor behind the presence of these harmful species associated with pathologies.

A review published in Science estimates that 2 % of rodent species are hyper-reservoirs, hosting and transmitting more than three pathogens to humans, including Lyme disease, Lassa fever and plague. In addition, the authors estimate that 10 % of rodents are reservoirs for one to three pathogens. These are especially so-called synanthropic species - animals that live close to humans and are able to adapt to these environments - such as black rats, Norway rats and house mice.

An international team with Spanish participation has developed a database with the metagenome of bacteria, fungi, and yeasts present in more than 2,500 foods, mostly dairy products, followed by beverages and fermented meats. The authors identified more than 10,800 microorganisms, half of which were previously unknown species. The study, published in Cell, shows that food-associated microorganisms are present in 3% of the adult gut microbiome and 56% of that of newborns.

Researchers at France's National Institute of Public Health have identified priority pathogens for wastewater surveillance during the Paris Olympic and Paralympic Games - to be held from 26 July to 11 August and 28 August to 8 September, respectively. The six pathogens selected, as reported in Eurosurveillance magazine, were poliovirus, influenza A virus, influenza B virus, mpox virus, SARS-CoV-2 and measles virus. Their choice was based on three criteria: analytical feasibility, relevance to the Olympic Games and characteristics of the pathogens, and their value in informing public health policy. In recent weeks, higher than recommended levels of E. coli bacteria have been found in the Seine River, according to the Associated Press.

A new study in mice, published in Science Immunology, challenges the so-called 'hygiene hypothesis', the idea that a contributing factor to allergies is that there is an under-stimulated immune system that has not seen enough exposure to germs from current hygienic conditions. In the research, laboratory mice still developed allergies when exposed to various microbes.