virology

According to the results of a phase 2 trial, an oral norovirus vaccine generated a strong mucosal immune response and even reduced viral shedding in vaccinated volunteers. Signs of the vaccine's efficacy support its potential to address the lack of safe and reliable vaccines against this virus, which is a major cause of gastrointestinal infections worldwide. The results were published today in the journal Science Translational Medicine.

A team of researchers from the USA has analyzed the B lymphocytes of seven healthy people in whom no exposure to H5 influenza viruses, such as the avian flu virus, had been documented. The results show that they present antibodies capable of recognizing this type of virus, which, according to the authors, could represent “a first line of defense” in the event of a pandemic. The results are published in the journal Science Immunology.

In Rwanda, according to the latest ECDC data, 25 cases and 11 deaths have been detected in what is already the third largest outbreak of the Marburg virus to date. The WHO considers the overall risk to be low and possible imported cases from Belgium and Germany - reported only yesterday in Hamburg - have proved to be false alarms. What is of concern is the national and regional spread of a virus for which mortality can be as high as 88% and for which there is no treatment or vaccine. In this article we answer the main questions.

A study carried out in China has analyzed tissues from 461 fur animals, mostly farm-raised. They found 125 virus species, 39 of which presented a high risk of interspecies transmission. According to the authors, who publish the results in the journal Nature, “there is a need for more extensive and regular surveillance to assess the public health risks that could result from fur animal farming”.

The sperm of men infected with high-risk genotypes of the human papillomavirus (HPV) suffers more damage from oxidative stress and has a weaker immune response, which can lead to reduced fertility. This is one of the conclusions of a study published in the journal Frontiers in Cellular and Infection Microbiology. The research compared the semen of 20 adults infected with high-risk genotypes, seven infected with low-risk genotypes, and 43 adults without infections.

With the increase in cases of mpox, the European Union's Health Security Committee met on Monday. According to the Ministry of Health, the meeting concluded ‘with recommendations very similar to those previously issued by the WHO and the ECDC’. The risk of the likelihood of mpox spreading to the general EU population is currently considered to be ‘low’, although it increases in populations with close contact with diagnosed cases and in particularly vulnerable people. Further imported cases in the EU are not excluded and vaccination of the general population is not recommended. In addition, the HSC does not recommend border control.  
 

Sweden's public health agency issued a statement on Thursday indicating that a person has been diagnosed with mpox - formerly called monkeypox - caused by variant clade I. According to the Swedish agency, this is the first case of this variant to be diagnosed outside the African continent. The person would have been infected during a stay in a part of Africa where there is an outbreak of this variant of mpox, according to the statement. The announcement comes a day after the World Health Organisation declared the mpox outbreak a public health emergency of international concern.

Researchers at France's National Institute of Public Health have identified priority pathogens for wastewater surveillance during the Paris Olympic and Paralympic Games - to be held from 26 July to 11 August and 28 August to 8 September, respectively. The six pathogens selected, as reported in Eurosurveillance magazine, were poliovirus, influenza A virus, influenza B virus, mpox virus, SARS-CoV-2 and measles virus. Their choice was based on three criteria: analytical feasibility, relevance to the Olympic Games and characteristics of the pathogens, and their value in informing public health policy. In recent weeks, higher than recommended levels of E. coli bacteria have been found in the Seine River, according to the Associated Press.

The World Health Organisation (WHO) has announced that a 59-year-old man infected with the H5N2 avian influenza virus died in Mexico on 24 April. This is the first confirmed human infection with the virus. The patient had multiple underlying medical conditions and had been bedridden for three weeks for other reasons before showing symptoms. The source of infection is unknown. The WHO assesses the risk to the general population as low. 

Since the first case of epizootic haemorrhagic disease (EHD) in Spain was detected in cattle in November 2022, it has spread among farms in several autonomous communities in dozens of outbreaks. The mosquito-borne disease does not affect humans, but has the potential to cause economic losses.