pregnancy

A healthy diet during pregnancy is associated with a lower likelihood of children being diagnosed with autism or communication difficulties, according to a study. The research team did not find a correlation between prenatal diet and repetitive and restricted behaviors (characteristic of these disorders). The analysis is published in JAMA Network Open and gathers data from more than 96,000 mother-child pairs in England and Norway.

Management of gestational diabetes should include earlier testing during pregnancy, as well as testing in the postpartum period, according to a series of papers published in The Lancet. Screening is usually done during the second half of pregnancy, but the authors note that diagnosis and treatment is especially beneficial before 14 weeks of pregnancy. 

A study conducted in Spain and five other European countries shows that exposure to mixtures of endocrine disruptors during pregnancy is associated with metabolic health problems in children. The research, published in JAMA Network Open, followed more than 1,100 mother-child pairs between 2003 and 2016 and found a correlation between measures of metabolic dysfunction in children aged 6-11 years, and their prenatal exposure to chemicals such as metals or organochlorine pesticides, among others. According to the authors, these results could be related to the current increase in metabolic syndrome across the lifespan, which results in an increased risk of cardiovascular disease and type 2 diabetes. 

Un estudio analizó la edad biológica de más de 1.700 participantes utilizando seis relojes epigenéticos diferentes. Los resultados mostraban que cada embarazo individual reportado por una mujer se correlacionaba con un envejecimiento biológico adicional de dos a tres meses. Estos efectos persistían incluso cuando se tenían en cuenta el estatus socioeconómico, el tabaquismo, la variación genética y la urbanidad del entorno de los participantes. El estudio se publica en PNAS. 

The NEJM publishes the results of a phase III clinical trial conducted by GSK that had to be suspended due to a safety signal. The study shows that newborns of vaccinated mothers had a lower risk of experiencing severe events associated with the respiratory syncytial virus (RSV), but also a higher risk of being born prematurely.

Women who follow vegan diets during pregnancy may have an increased risk of developing preeclampsia and giving birth to underweight newborns, suggests an observational study published in Acta Obstetricia et Gynecologica Scandinavica. In the investigation, more than 65,000 women identified themselves as omnivores, more than 800 as vegetarians -in some of their different modalities- and 18 as vegans.

A study that has analysed more than three million pregnancies with more than 130,000 miscarriages has concluded that the use of benzodiazepines during pregnancy is associated with an increased risk of miscarriage. The results are published in the journal JAMA Psychiatry.

Babies' brains specialise in their native language from pregnancy, according to a study carried out in France. The research team used encephalograms to measure the brain activity of 33 infants born to French-speaking mothers while listening to a story in French, English or Spanish. The results provide "the most compelling evidence to date that language experience already shapes the functional organization of the infant brain, even before birth," the authors write in Science Advances.

A study in mice found "mild metabolic and neuropsychological malprogramming" in the offspring of females who, during gestation and lactation, had ingested emulsifiers, substances used to improve the texture of ultra-processed foods. The article, led by a team from IDIBAPS in Barcelona and published in PLoS Biology, states that the consumption during these periods of carboxymethylcellulose and polysorbate 80 - two common emulsifiers - diluted in water was associated with metabolic and cognitive deficits in the mouse offspring.

The European Medicines Agency (EMA) has recommended marketing authorisation in the European Union for Abrysvo vaccine to protect against respiratory syncytial virus (RSV) disease in infants up to six months of age. It is the first vaccine of its kind indicated for passive immunisation of newborns through administration to the mother during pregnancy. It is also indicated for people over 60 years of age. The European Commission now has to decide on its EU-wide marketing authorisation.