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Intermittent fasting weight loss comparable to that of calorie restriction diets

Intermittent fasting has similar effects to calorie-restricted diets in terms of weight loss, concludes a meta-analysis, published in The BMJ, pooling the results of 99 previous clinical trials. Of three types of intermittent fasting (alternate-day fasting, time-restricted eating and all-day fasting), intermittent fasting has a higher impact on weight reduction compared to continuous energy restriction, the study adds.

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A genetic variant has been discovered that increased height and accelerated metabolism in modern humans

A team from China has analysed the genetic data of more than 450,000 people and identified a variant in a gene that contributed to increased height and basal metabolic rate in modern humans, especially when meat consumption increases. In addition to providing insight into evolutionary processes, the finding ‘also has important implications for understanding susceptibility and resistance to contemporary metabolic disorders such as type 2 diabetes, obesity and metabolic syndrome,’ according to the authors. The results are published in the journal Cell Genomics.

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Study suggests eating ultra-processed foods may accelerate early Parkinson's symptoms

Consumption of ultra-processed food is associated with an increased likelihood of having prodromal signs of Parkinson's disease - symptoms that precede the disease - says a study published in Neurology. The analysis is based on data from more than 42,000 healthcare professionals in the US, followed for up to 26 years.

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Two mixtures of food additives are associated with the development of type 2 diabetes

Consuming certain mixtures of common food additives is linked to a slightly increased risk of developing type 2 diabetes, according to an analysis of data from more than 108,000 adults in France. The study, published in PLoS Medicine, identified five mixtures of additives frequently used in ultra-processed foods and concluded that two of them are associated with the disease: the first mixture consisted mainly of emulsifiers, preservatives and a colouring agent, and the second of acidifiers, acidity regulators, colouring agents, artificial sweeteners and emulsifiers.

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A high-fat diet favours metastasis of the most aggressive breast cancer in mice

A team led by the Spanish National Cancer Research Centre (CNIO) has shown in mice that a high-fat diet increases metastasis in triple-negative breast cancer, which has the worst prognosis. In addition, it has identified several of the mechanisms that would explain this, such as the activation of platelets and coagulation, which would help the tumour hide from the body's defences and prepare the so-called ‘pre-metastatic niche’. According to the researchers, who published the results in Nature Communications, ‘this mechanism could be extrapolated to other tumour types and other organs’. The results suggest that ‘dietary intervention, together with the control of platelet activity, may increase the efficiency of certain anti-tumour treatments’.

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What is inflammation: a guide to information and how to avoid falling for ineffective remedies

Inflammation is all the rage. In fact, anti-inflammatory diets that claim to fight it. This is attested to by best-selling books and influencers, ready to give us the latest tips on how to lose weight, or rather, how to reduce inflammation. But what's the truth in all this, and what does inflammation have to do with being overweight? 

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High coffee consumption associated with lower risk of head and neck cancer, study finds

According to a meta-analysis of 14 studies involving more than 25,000 people, drinking more than four cups of coffee per day was associated with a lower incidence of head and neck tumors. Drinking between none and one cup of tea was also associated with a slightly decreased risk, although daily consumption of more than one cup of tea was associated with an increased risk of developing laryngeal cancer. The results are published in the journal Cancer

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Cells ‘remember’ obesity through epigenetic changes, which could explain the ‘yo-yo effect’

Adipose tissue retains a ‘memory’ of obesity through cellular transcriptional and epigenetic changes that persist after weight loss, which may increase the likelihood of regaining weight, experiments in human and mouse cells show. The findings, published in Nature, could help explain the problematic ‘yo-yo effect’, the rapid weight rebound often seen with dieting. 

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