In mice, a therapy based on editing regulatory T-cells can suppress an immune reaction against gluten, according to a study in Science Translational Medicine. Studies in animals with coeliac disease would be needed to assess the efficacy of this cell therapy in restoring gluten tolerance, the authors say.
Inflammation is all the rage. In fact, anti-inflammatory diets that claim to fight it. This is attested to by best-selling books and influencers, ready to give us the latest tips on how to lose weight, or rather, how to reduce inflammation. But what's the truth in all this, and what does inflammation have to do with being overweight?
According to a meta-analysis of 14 studies involving more than 25,000 people, drinking more than four cups of coffee per day was associated with a lower incidence of head and neck tumors. Drinking between none and one cup of tea was also associated with a slightly decreased risk, although daily consumption of more than one cup of tea was associated with an increased risk of developing laryngeal cancer. The results are published in the journal Cancer.
Eating five servings of dark chocolate a week is associated with a reduced risk of type 2 diabetes, according to a long-term US study published today in The BMJ. The research did not find this association with milk chocolate.
Adipose tissue retains a ‘memory’ of obesity through cellular transcriptional and epigenetic changes that persist after weight loss, which may increase the likelihood of regaining weight, experiments in human and mouse cells show. The findings, published in Nature, could help explain the problematic ‘yo-yo effect’, the rapid weight rebound often seen with dieting.
The DANA that devastated the province of Valencia on 29 October, leaving more than 200 people dead and many missing, has been followed by another one, still located over the peninsula. How can we adapt to these extreme phenomena? What repercussions do they have on public health? How can the public prepare for them? The Science Media Centre España organised a briefing session with two experts and an expert from the CSIC to discuss these questions.
An international report by the Global Commission on the Economics of Water says the water crisis puts more than half of the world's food production at risk by 2050. It also claims that it threatens an average loss of 8% of GDP in countries around the world by 2050, with losses of up to 15% in the lowest income countries.
An international team of researchers has analyzed various data sources and scientific literature and identified 3,601 chemical substances in human samples such as blood, urine or breast milk that are known to be in contact with food, for example, because they are used in packaging. According to the authors of the study, “this work shows that food contact materials are not completely safe, even if they comply with regulations, because they transfer known substances to food". The research is published in the Journal of Exposure Science and Environmental Epidemiology.
An international team with Spanish participation has developed a database with the metagenome of bacteria, fungi, and yeasts present in more than 2,500 foods, mostly dairy products, followed by beverages and fermented meats. The authors identified more than 10,800 microorganisms, half of which were previously unknown species. The study, published in Cell, shows that food-associated microorganisms are present in 3% of the adult gut microbiome and 56% of that of newborns.
A ketogenic diet improves the results of a pancreatic cancer therapy in mice, according to a study published in Nature. The US research team fed the animals a high-fat, low-carbohydrate diet before administering them a new drug, currently in clinical trials; in the absence of glucose, the body converts fat into ketone bodies. The drug blocks the metabolism of fat - the cancer's only source of energy while the mice are on this diet - and slows the growth of pancreatic tumours.