Reacción a "The ‘dark transcriptome’ has been used to reduce inflammation in mice and human cells"

The development of techniques for mass RNA sequencing (ribonucleic acid produced by transcription of DNA from our genome) is opening a field of scientific exploration of unexpected dimensions. We have already seen how messenger RNA–based vaccines have become part of everyday life, and small RNA molecules with low molecular weight are also being used in therapeutic treatments.

The study carried out in Canada by Janice Pang and colleagues and published in the scientific journal Science Signaling rigorously and pioneeringly describes the use of three long RNAs (lncRNAs) to control the inflammatory response in a model of induced inflammation in mice and in human macrophages. Considering that tens of thousands of these long RNAs still remain to be studied in order to understand their mechanisms of action, the possibility of their therapeutic use opens a very interesting field of research with multiple applications for the treatment of diseases for which we still do not have adequate drugs.