Autor/es reacciones
James Pelletier
Head of the Microcellular Biophysics Group at the National Center for Biotechnology (CNB-CSIC)
The interdisciplinary work of Kate Adamala and her colleagues is linked to several international initiatives, such as the EU Synthetic Cell Initiative, the U.S.-based Build-a-Cell community, and the SynCell Asia Initiative.
What is striking is how they have integrated different established techniques into a single system. To compare synthetic cells, some important questions are: What is encoded in the genome? What is the nutrient source? And what is its functionality?
Spudcell is an in vitro system that requires complex biomolecules, such as purified ribosomes, in its nutrient medium; it has limited capacity to grow and divide. In comparison, bacteria such as the minimal cell from the J. Craig Venter Institute can synthesize their own ribosomes and grow and divide exponentially. These are complementary approaches to studying the molecules of life.
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