Centro Nacional de Biotecnología (CNB-CSIC)

National Biotechnology Centre (CNB-CSIC)

Information
C/ Darwin nº 3, Campus de Cantoblanco 28049 Madrid

cancer, covid-19, gene editing, rare diseases, immunology, microbiology, nanoscience, AIDS / HIV, transgenics
Contact
Susana de Lucas
Communication and scientific dissemination
divulgacion@cnb.csic.es
91 585 48 42

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SMC participants

Co-director of the Microbiome Analysis Laboratory and Research Professor

Co-director of the coronavirus group at the National Biotechnology Centre (CNB-CSIC)

Research professor at the National Biotechnology Centre (CNB-CSIC) and at the CIBERER-ISCIII

 

CNB-CSIC scientific researcher at the Instituto de Investigación Sanitaria de Santiago de Compostela, IDIS

Virologist at the National Center for Biotechnology (CNB-CSIC)

Researcher at the National Biotechnology Centre (CNB-CSIC)

Researcher specialized in ecology and evolution of antibiotic resistance.

Virologist at the National Biotechnology Centre (CNB-CSIC)

Contents related to this centre
HIV

The Science group is simultaneously publishing four papers (two in the journal Science, one in Science Immunology and one in Science Translational Medicine) that include advances in a sequential vaccination strategy for an effective HIV vaccine. The methods employed aim to obtain broad-spectrum neutralising antibodies and one of the proposals is already in clinical trials. 

mouse

Two independent research teams have managed to regenerate brain circuits in mice using neurons cultivated from rat stem cells. Today, both studies were published in the journal Cell. The research, in which chimeras of different species were generated, delve into how brain tissue forms and present new opportunities for restoring lost brain function due to diseases and aging.

Epigenetic

Epigenetic editing is a technique that aims to alter gene expression without the need to modify the DNA sequence, as gene editing techniques do. In this way, Italian researchers have succeeded in silencing the PCSK9 gene in mice, thereby reducing cholesterol levels by half for at least a year. According to the authors, and assuming further evaluation is needed, their platform "could lay the foundations for the development of this type of therapy". The results are published in the journal Nature.

Bacterias

Cresomycin, a new synthetic molecule, exhibits robust efficacy against multiple evolutionarily divergent forms of antimicrobial resistance (AMR), according to a study published today in Science. By structurally analyzing how antibiotics bind to ribosomes of various bacterial species, researchers developed a new antibiotic molecule that adopts the exact conformation necessary for ribosomal binding.

monkey

A team of Chinese researchers report today in the journal Nature Communications the successful cloning of a rhesus monkey, with a healthy placenta, which survived for more than two years. According to the authors, this could improve the efficiency of the monkey cloning process, which so far is very low. Previously, different teams have cloned more mammalian species, including 'Dolly the sheep' and another species of macaque (Macaca fascicularis).

brain

A team led by the Princess Máxima Pediatric Oncology Center and the Hubrecht Institute (The Netherlands) has generated small 3D brain models--known as organoids--from human fetal brain tissue. Until now, these brain organoids-which attempt to resemble real organs on a miniature scale-were grown in the laboratory using pluripotent or embryonic stem cells. The new technique, published in the journal Cell, allows regions of brain tissue to self-organize into three-dimensional brain structures. The authors used these organoids and the CRISPR-Cas9 tool to simulate the development of one type of brain tumor, glioblastoma, and see how it responded to different drugs.

anemia

The European Medicines Agency (EMA) has recommended approval of the first drug in the European Union to use the CRISPR/Cas9 gene-editing technique. The drug, Casgevy, is indicated for the treatment of two rare inherited diseases, beta thalassaemia and sickle cell disease (sickle cell anaemia), caused by genetic mutations that affect the production or function of haemoglobin, the oxygen-carrying protein in red blood cells. Both conditions are debilitating and potentially fatal. The EMA opinion will be sent to the European Commission for a decision on an EU-wide marketing authorisation.

organs

A study of more than 5,000 patients has developed a method to predict the biological age of our organs. They have analysed more than 4,000 proteins present in the blood and used machine learning models adapted to 11 different organs. According to the authors, almost 20 % of the population has accelerated organ ageing, which in many cases is associated with an increased risk of mortality of between 20 and 50 %. The results are published in the journal Nature.

Pneumonias

Since mid-October, northern China has reported an increase in influenza-like illness compared to the same period in the previous three years. On 21 November, the media and the ProMED system reported outbreaks of pneumonia of undiagnosed cause in children in northern China. According to the World Health Organization (WHO), it is unclear whether these are related to the overall increase in respiratory infections previously reported by the Chinese authorities or are separate episodes. In a statement, the WHO has officially requested detailed information from China on this increase in respiratory illnesses and outbreaks of childhood pneumonia.

Nobel

The Karolinska Institute has awarded the Nobel Prize in Medicine or Physiology to Katalin Karikó and Drew Weissman for their groundbreaking discoveries, which have radically changed our understanding of how mRNA interacts with our immune system, and made it possible to develop vaccines at unprecedented speed during the covid-19 pandemic.