Autor/es reacciones
Juan Carlos Espinosa Martín
Senior Scientist at the Animal Health Research Centre (CISA) of the National Institute for Agricultural and Food Research and Technology (INIA-CSIC)
It is a very important study because:
- It opens up a new therapeutic avenue for these fatal diseases which, in many cases, affect families carrying mutations in the prion protein whose members wait with dread for the appearance of the characteristic clinical signs. It is worth mentioning that one of the authors of the paper is a carrier of such a mutation.
- It is a model therapy for the set of diseases associated with the misfolding and accumulation of pathogenic proteins that cause neurodegeneration and known as prion-like diseases such as Alzheimer's, Parkinson's or amyotrophic lateral sclerosis (ALS). Therefore, the implications of epigenetic control of target protein expression go beyond the field of prion diseases.
EN