Marcos Luján Galán
Head of the Urology Unit at the Infanta Cristina Hospital, researcher in the Spanish branch of the European Randomized Study of Screening for Prostate Cancer
The study is a literature review with a clear position against current prostate cancer screening policies.
Screening policies in different high-income countries are similar: the doctor explains to the patient the pros and cons of doing a PSA test, and the patient decides whether to have one. The authors of this paper conclude in their review that this approach does not have the desired effect: iit increases the risk of detecting cancers of little clinical relevance (overdetection, which can be as high as a staggering 50%), and of unnecessary treatment (overtreatment). It also introduces inequality in healthcare, as wealthier groups end up being tested more frequently.
Another undesirable outcome is that a high proportion of older men are being screened. All scientific societies agree in discouraging screening in men whose life expectancy is less than 10-15 years, as this is the average time it takes for prostate cancer detected by screening to produce symptoms due to disease progression (in other words, the individual would die of other causes due to his age before prostate cancer had time to kill him). The chance of dying from prostate cancer in your remaining life, if you have a normal PSA level at age 75, is virtually zero. This is why it is not recommended to continue screening beyond a certain age. It is precisely the current ‘shared decision-making’ approach that causes the screening rate in older men to be worrying.
This policy is currently in force in Europe (European Association of Urology, EAU) and is directly adopted by the AEU (Spanish Association of Urology).
What do the authors propose?
- That screening programmes should be controlled by governments. They should choose the candidates (and provide access to the test), and adopt a follow-up protocol according to the risk profile of the individual (the follow-up interval would be different according to the level of the first PSA, for example).
- As an alternative to the above, restrict access to PSA testing, to be prescribed by a urologist in the presence of symptoms or specific risk profiles (family history, certain genetic mutations, etc.).
Recommendations for patients? In my opinion, in the absence of an established government programme, in patients without a specific risk profile (family history, certain genetic mutations, etc.) and in the absence of symptoms, I would be inclined not to perform PSA indiscriminately.