Reacción a "Reaction to the finding that mice live longer if they eat little and only when active "

It is very elegant work. Its result does not surprise me, because in fact fasting for defined periods of time, and taking into account circadian rhythms of activity, is a traditionally established practice in many cultures. The paper highlights that what is important for longevity is not so much the reduction of calories consumed, but that calorie restriction is maintained over a certain period of time in accordance with circadian rhythms (the biological clock that regulates physiological functions), so that intake is adjusted to the body's activity rhythms. 

One could easily test the benefits of calorie restriction in humans over defined periods of time by measuring specific parameters, such as metabolic, inflammatory, cognitive, memory, exercise, etc. indicators. So I don't see a problem with this type of work being done in humans by analysing these markers. However, to measure the benefits of calorie restriction on longevity we will need a long-term experiment.