Silvia Osuna Oliveras
ICREA Researcher at the Computational Chemistry and Cathalisis Institute (IQCC) from the Girona University
I am very pleased that the field of computational protein design is being recognized with the Nobel Prize in Chemistry along with the development of the AlphaFold2 tool. AlphaFold2 demonstrated at the protein-structure prediction challenge (CASP) conference in 2020 its ability to predict the 3D structure of proteins with high accuracy, and since then the number ofdeep learning-based methods for its application in the field of protein design has increased exponentially. “It will change everything”, ‘it's a game-changer’, these are some of the headlines that were published at the time.
The reality is that the field of protein design is advancing at a great speed, every day scientific articles focused on artificial intelligence are published, and in the last 4 years we have advanced a lot, protein designs that previously needed years of research now thanks to AlphaFold2 and the methods developed by Baker's group (among others) can be solved in a matter of minutes.