Pluvio Coronado
professor of Obstetrics and Gynaecology at the Universidad Complutense de Madrid, president of the Spanish Association for the Study of Menopause (AEEM)
The study provides robust evidence based on a substantial sample size and confirms a previously documented association whereby PCOS, now referred to as PMOS, is linked to an increased cardiovascular risk through its association with diabetes, obesity, and hormonal disorders. This study strengthens the existing evidence, with the association remaining significant even after adjustment for recorded cardiovascular risk factors. However, by design, it is not a study that can establish causality, nor does it allow us to conclude that the residual risk is necessarily attributable to biological mechanisms intrinsic to the syndrome itself, although in my view the findings do point in that direction.
The study reinforces the importance of early assessment of cardiometabolic risk factors in these women and highlights the need for targeted preventive strategies to reduce cardiovascular events. In particular, attention should be given to maintaining a healthy diet, preventing obesity, and encouraging regular physical activity, although these measures are, of course, advisable for everyone.