Reacción a "Reactions to study linking consumption of two sweeteners to alterations in glucose and the microbiome "

This is a good study. However, as usual, one can always see 'drawbacks'. Of the 19 sweeteners approved in the EU, only four appear in this article, so no results can be extrapolated. As we also found in a recently published review, the authors go so far as to observe an effect on the gut microbiota with altered glycaemic response for saccharin and sucralose. 

In any case, although the N (the number of participants in the study) is fine (120), there are only 20 in each arm of the study. In addition, the age range is very wide (18-70), both sexes are included (something that should always be taken into account because there are sex differences in terms of microbiota results) and the intervention time is short, only two weeks. In terms of nutritional status, there are several groups and obesity is not taken into account, only overweight. 

In principle, it would be preferable to differentiate by case, by nutritional situation, by pathology, even by geographical area, since in Latin America the population has been consuming different types of sweeteners for years and could possibly have adapted their microbiota. 

I think that, in general, taking these points into account, it may be difficult to draw conclusions.