Eloy Rodríguez Rodríguez
Head of the Neurology Department at the Marqués de Valdecilla-IDIVAL University Hospital and Associate Professor of Medicine in the Department of Medicine and Psychiatry at the University of Cantabria
It is a very interesting study, methodologically well done, which adds to a growing body of evidence pointing to the protective effect of aerobic exercise, in this case moderate exercise, against Alzheimer's disease. In my opinion, the most interesting aspect is the long observation period (14 years) and how well the subjects in the cohort have been studied, allowing us to discern that the underlying mechanism is the reduced accumulation of tau protein.
The accumulating evidence should guide public health policies towards the promotion of physical exercise in the general population and, especially, in high-risk populations, using it as a prevention tool.