Marcos López Hoyos
Scientific Director of the Valdecilla Health Research Institute (IDIVAL) and Professor of Immunology at the University of Cantabria
The repeated booster strategy does not seem to make much sense at the present time. Repeating a booster with the same preparation of the original vaccine against the original Wuhan virus does not seem to make much sense if we want to induce neutralising antibodies against the new variants. They should include at least some of the variants such as delta or omicron. In any case, the T-cell response that protects us has already been induced and no new booster is needed for the memory T-cell part. In addition, the booster should ideally stimulate the response against other components of the virus and not necessarily against the S protein. The strategy of booster every few months does not seem to be of value. There is also no evidence that it is harmful, although there is no clear evidence on this either.