Raluca M. Fratila
Ramón y Cajal researcher at the University of Zaragoza working in the field of bioorthogonal chemistry
The term 'click chemistry', coined in 2001 by K. Barry Sharpless and Morten Meldal, includes a series of chemical reactions that possess unique characteristics in terms of selectivity, fast kinetics, simplicity, high yields, absence of side products and robustness. Click chemistry has brought enormous advances in chemistry, nanotechnology and materials science.
When, in addition to all the above characteristics, the compatibility of these reactions with the biological conditions of living cells and organisms is added as a requirement, the impact of Carolyn Bertozzi's development of bioorthogonal chemistry is evident. Bioorthogonal chemistry has represented a true revolution for biology, biochemistry and nanobiotechnology, providing unprecedented tools for the visualisation and analysis of biomolecules in their biological environment and giving rise to new diagnostic and therapeutic applications.
It is, of course, a well-deserved recognition of the incredible impact of click chemistry and bioorthogonal chemistry in different areas of science. As a researcher working in the field of bioorthogonal chemistry applied to nanotechnology, I warmly welcome this fantastic achievement - my sincere congratulations to all three award winners!