University of Zaragoza

A team from the Children's Hospital of Philadelphia and Penn Medicine (United States) has successfully treated a baby diagnosed with a rare genetic disorder using personalised CRISPR gene editing therapy. The baby, known only by the initials KJ, was born with a rare metabolic disease known as severe carbamoyl phosphate synthetase 1 (CPS1) deficiency. After spending the first months of his life in hospital on a very restrictive diet, KJ received the first dose of his tailored therapy in February 2025, between six and seven months of age. The treatment, which is being used for the first time for this type of disorder, was administered safely, and the baby is now growing well and improving. The case is detailed in a study published by The New England Journal of Medicine (NEJM).

At this time, it is unknown what caused the massive power outage that left millions of people without electricity on the Iberian Peninsula on Monday. The influence of renewable energy sources is also unknown.

An international team has found that aspirin is capable of reducing the appearance of metastasis in mice, by enabling the activation of T lymphocytes capable of recognising tumour cells. The research showed that several different mouse cancer models — including breast cancer, colon cancer and melanoma — treated with aspirin showed a lower rate of metastasis in other organs, such as the lungs and liver, compared to untreated mice. According to the authors, who publish the results in the journal Nature, ‘the finding paves the way for the use of more effective anti-metastatic immunotherapies’.

An international team of scientists from the KM3NeT collaboration has detected the signal from the highest-energy cosmic neutrino to date, some 30 times higher than those previously detected. The result suggests that the particle came from beyond the Milky Way, although its precise origin has yet to be determined. The results are published in the journal Nature. 

A study by a team from the ClimaMeter project claims that the intensification of rainfall from the DANA that devastated Valencia and other regions on 29 October is mainly attributed to human-induced climate change. Natural climate variability, on the other hand, probably played a modest role. According to the analysis, this DANA was driven by very exceptional weather conditions. The work also shows that the DANA-like depressions that cause flooding in the southeastern peninsular are up to 15 % wetter than they were in the past. In addition, temperatures are up to 3°C warmer, which favours storm formation in these events over the Mediterranean basin. 

An international team with Spanish participation has analysed which day of the week has the highest risk of suicide mortality, and it is Monday. The research, published in The BMJ, includes more than 1,700,000 suicide cases registered in 26 countries - including Spain - from 1971 to 2019. The data also show a sharp increase in the risk of suicide on New Year's Day in most of the countries analysed. Taking these results into account, the authors propose that they should be used to define plans and awareness-raising campaigns.

An international report by the Global Commission on the Economics of Water says the water crisis puts more than half of the world's food production at risk by 2050. It also claims that it threatens an average loss of 8% of GDP in countries around the world by 2050, with losses of up to 15% in the lowest income countries. 
 

Lithium, a material widely used for battery production, is typically extracted from rocks and concentrated brines, but these reserves are expected to run out by 2080. The alternative is to evaporate more diluted brines (such as seawater), but the traditional process is inefficient, polluting, and consumes large amounts of water. Two new studies published in Science propose two more viable and environmentally friendly alternative methods: the first uses a membrane that filters lithium through a transpiration system similar to that of plants, requiring only solar energy. The second combines electrodes to mimic a battery and move lithium from the brine (cathode) to fresh water (anode).

E-cigarettes, vapes, pods, mods... The popularity of these devices continues to grow, especially among young people. According to a Spanish survey, more than half of the adolescents aged 14 to 18 have used them at some point. Vaping control varies from country to country: in Spain, vaping products have been regulated since 2017 and the new anti-smoking plan aims to equate their legislation to that of tobacco, while the United States imposes fewer restrictions. In this brief guide, we explain what is known and not known on controversial issues such as the safety of electronic cigarettes, their risks or whether they are useful to quit tobacco.

In 2022, 62 million tonnes of e-waste were generated worldwide, a figure 82% higher than the 34 million tonnes recorded in 2010, according to a United Nations report. The 2022 figure represents an average of 7.8 kilograms per capita per year worldwide, compared to 19.6 kg in Spain. Only 22.3% of this amount of global e-waste was documented as properly collected and recycled, says the Global E-waste Monitor 2024.