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Reaction to study associating lung infections in infancy with increased risk of death from respiratory disease in adulthood

People who had a lower respiratory tract infection—such as bronchitis or pneumonia—before the age of two have twice the risk of premature death from respiratory disease in adulthood, according to a study published in The Lancet. The research is based on long-term data from over 3,500 people born from 1946 onwards in England, Scotland and Wales. According to the study, one in five premature deaths in this representative sample could be due to respiratory infections. The team adjusted their estimate by taking into account factors such as socioeconomic status in childhood and smoking in adulthood.  

08/03/2023 - 00:30 CET
enfermedad respiratoria

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Joan Soriano - enfermedad respiratoria EN

Science Media Centre Spain

This is a very interesting study because of its long follow-up over time (up to eight decades) in a representative sample of the British population. It finds that the risk of dying from respiratory causes is twice higher in those participants who had repeated respiratory infections during childhood, especially those who had them before the age of two, or who suffered more than three episodes.  

The study highlights how difficult it is to confirm with hard evidence something that we often observe in the clinic: children with poor respiratory health are often adults who are prone to disease, or die earlier.  

In this cohort, one in five premature respiratory deaths is attributed to repeated respiratory infections during childhood; by comparison, two in five are due to smoking.  

Adjusting for low socio-economic class or overcrowding (defined here as sleeping in the same room as other people) is relevant.  

The study has some limitations: it didn’t include respiratory function measurement via spirometry or peak-flow, and didn’t take into account compulsory vaccinations at these ages, which probably affected migrants and the lowest-income groups.

The author has not responded to our request to declare conflicts of interest
Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study
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The Lancet
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James Peter Allinson et al.

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  • Observational study
  • People
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