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Reactions to study indicating that neither e-cigarettes nor nicotine patch use are associated with adverse effects in pregnancy

In pregnant women, neither regular use of electronic cigarettes nor nicotine replacement therapy is associated with unfavorable effects, according to a trial involving 1,140 pregnant smokers in England and Scotland. The authors analyzed the association between nicotine consumption by the two routes - vaping and nicotine patches - with parameters including infant birth weight, miscarriages, premature births and respiratory symptoms in the mother. The research is published in the scientific journal Addiction.

 

17/01/2024 - 09:00 CET
Expert reactions

Caitlin Notley - vapeadores embarazo EN

Caitlin Notley

Professor of Addiction Sciences at Norwich Medical School, University of East Anglia (UEA)

Science Media Centre UK

This paper presents high quality evidence, as a secondary analysis of data from the first UK trial of e-cigarettes for smoking cessation during pregnancy. 

Tobacco smoking is a major contributor to poor pregnancy outcomes, including stillbirth, miscarriage and low birthweight. Helping people to stop smoking completely, as quickly as possible, is the best way to improve pregnancy outcomes.  

In this study, the authors find that more people choose to use e-cigarettes than nicotine replacement therapy (NRT), suggesting that people who are pregnant prefer e-cigarettes as a way of quitting smoking. Preference is important because if people can choose something they like, they are likely to have a better chance of staying smokefree. 

It is really reassuring that people who quit smoking using an e-cigarette during pregnancy in this study had better pregnancy outcomes than women who continued to smoke tobacco, and did not have any worse outcomes than people who do not smoke at all. This provides reassurance of the safety of e cigarettes for smoking cessation during pregnancy. NRT is already recommended for use during pregnancy for smoking cessation. The findings of this study suggest that e cigarettes do not differ in safety profile from NRT. My reading of this evidence is that e-cigarettes could be viewed as a form of NRT and also can be recommended for smoking cessation to pregnant women, especially as tobacco smoking is so damaging.

Declares having received an honorarium from Vox media company for filming a 'nicotine explainer' on the role of nicotine in addiction. 

EN

Jamie Brown - vapeadores embarazo EN

Jamie Brown

Director of the Tobacco and Alcohol Research Group, and Professor of Behavioural Science, University College London (UCL)

Science Media Centre UK

Smoking in pregnancy is dangerous, and many people want to quit and reduce these risks. E-cigarettes are an effective way for people to quit smoking and these new findings may ease some worries of pregnant smokers who want to use them to quit smoking. 

An earlier analysis of this trial found a similar safety profile between those who were randomly given e-cigarettes compared with those given nicotine replacement therapy to quit smoking, but this may have resulted from a difference in the actual usage of the two products. This new study analysed the comparative safety based on their actual use, although this meant the two groups were no longer randomly selected. Taken together, the similar sets of results across the two different approaches are reassuring.

Declares having received unrestricted funding to study smoking cessation from Pfizer and J&J, who manufacture medically licensed smoking cessation treatments. 

EN
Publications
Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomised controlled trial
  • Research article
  • Peer reviewed
  • People
Journal
Addiction
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Authors

Francesca Pesola et al.

Study types:
  • Research article
  • Peer reviewed
  • People
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