Carlos Guijarro Herráiz

Statins are used to prevent atherosclerotic cardiovascular disease (ACD), a specific type of cardiovascular disease caused by the build-up of fatty plaque inside the arteries, which can lead to heart disease or stroke. A study published in The Lancet Healthy Longevity analysed the effect of stopping statins in adults aged 75 and over who were taking them preventatively, that is, without a history of atherosclerotic cardiovascular disease. The results showed that discontinuing treatment was no worse than continuing it in terms of all-cause mortality over a three-year period. According to the authors, these results support individualised decision-making regarding the discontinuation of statin treatment in older people, rather than a blanket recommendation to stop taking them.

Statins are a group of drugs widely used to lower cholesterol levels and reduce cardiovascular risk. Although they have been associated with various adverse effects, a meta-analysis of 19 clinical trials with more than 120,000 participants in total concludes that only four of the 66 side effects listed in the package inserts are caused by statins themselves and the risks are very low. The authors, who published their findings in The Lancet, recommend revising the current list of side effects on statin labels to better reflect the evidence so that patients and doctors can make clearer and more informed decisions about treatment.

In a study published in the journal Nature Medicine, a team of researchers from the National Center for Cardiovascular Research (CNIC) proposes a new cardiovascular risk factor to add to those already known. It is clonal hematopoiesis, a phenomenon caused by acquired mutations in blood stem cells. Furthermore, in a separate study published in the European Heart Journal, they suggest that the drug colchicine could serve to reduce its effects.