Aragón Health Research Institute

The HTAN (Human Tumor Atlas Network) consortium is simultaneously publishing 11 papers in different journals of the Nature group. These include analyses of the architecture of tumors and their environment in more than 2,000 patients and twenty different locations, which will make it possible to study how they start and evolve. Among the novelties found are new clues about the development of metastasis and resistance to treatments, and the finding that colorectal cancer can arise from multiple cells with different mutations that act collectively, instead of from a single initial clone as previously thought.

Seven studies published in Nature and Nature Medicine look at how lung cancer evolves, with genomic studies of more than 1,600 tumour samples taken from 421 patients in the TRACERx project. The research includes the most common type of lung cancer (NSCLC) and assesses why tumours sometimes recur, spread to other parts of the body or the effects of platinum-based chemotherapy.

Research to be published in the journal Nature identifies and characterizes the cells responsible for relapse in colon cancer. In addition, it proposes revising clinical guidelines and administering immunotherapy before surgery to try to avoid them