Gregorio Marañón Institute of Health Research
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Professor of Immunology in the Department of Immunology, Ophthalmology and ENT of the Complutense University of Madrid, member of the Gregorio Marañón Health Research Institute of Madrid and the Networked Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD)
Principal investigator at the Instituto de Investigación Sanitaria Gregorio Marañón
Principal investigator of the Neuromaternal research group
A study describes changes in a woman's brain during and after pregnancy, including a ‘pronounced’ decrease in grey matter volume and cortical thickness, and an increase in ventricular volume and cerebrospinal fluid. Some of the changes are maintained in the postpartum period; others reverse within months. The team performed 26 MRI scans and blood tests on one mother, from pre-conception until two years postpartum, and publish the results in Nature Neurology.
A team of researchers at Stanford University (USA) has developed a technique that makes animal tissues transparent in vivo and reversibly. Based on a food dye, they have tested it topically on mice. According to the authors, who publish their research in the journal Science, “this technology could make veins more visible for blood collection or help in the early detection and treatment of cancer”.
Five out of ten potential treatments move from animal studies to human studies; four to randomised controlled clinical trials; and one in 20 moves on to approval by regulatory agencies, an analysis estimates. Concordance between positive results in animals and in clinical studies is 86%, according to the study, published in PLoS Biology, which pools the findings of 122 published studies on 54 different human diseases.