Many of the mouse models used in laboratories show inconsistencies between their names and their genetic makeup, according to an analysis
A team from the United States analyzed 611 samples from 341 model mouse strains stored at the Mutant Mouse Resource and Research Centers (MMRRC), a research resource network supported by the National Institutes of Health (NIH). By comparing the identity of each strain with its actual genetic profile, they found that approximately half of the samples showed discrepancies. Although the expected engineered mutation was generally present and many inconsistencies were relatively minor, some had the potential to compromise the validity and reproducibility of the experiments by introducing hidden genetic variables that could alter biological outcomes. The findings are published in Science.
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