There is no point in continuing to administer reminder doses indiscriminately, I think it might even be counterproductive for some individuals. It is a mistake to try to maintain high levels of antibodies perpetually. Even more so when Omicron has shown partial escape of the antibodies generated by the vaccine, therefore a higher level of antibodies is needed to achieve the same neutralising action.

We must assume that with this vaccine against Omicron we cannot avoid infection in a sustained manner over time due to the natural loss of antibodies (especially in the respiratory mucosa, which are the key to avoid infection). This is not a problem for the vast majority of immunocompetent individuals who are able to cope with the virus without any problem, with conserved cellular immunity against all variants (as they do against all other viruses).

In the case of vulnerable people, I am more in favour of updating the vaccine to the omicron variant as soon as possible and starting a new primary vaccination schedule with the vaccine adapted to this variant, rather than a booster strategy with omicron, which does not seem to give good results. As long as this vaccine is not available, I think it makes more sense to carry out an exhaustive determination of immunity (cellular and antibodies) in these individuals and to select very carefully those who would benefit from additional doses. We must move away from indiscriminate vaccination by age groups and individualise the covid-19 vaccination strategy as soon as possible.