It is a very interesting study, which analyses more than 300,000 patients with data collected more than 50 years ago and which is published in one of the journals with the highest impact on reproduction, Human Reproduction. With these numbers we can get an idea of the magnitude and quality of the study by the urology team at the University of Utah led by Jim Hotaling.  

There are studies that have already analysed the relationship between male infertility and the possibility of suffering from different types of cancer, such as testicular cancer. The authors go further and look not only at the risk to the patient, but also at the risk of cancer for the offspring of these patients. The implications of this study would be to inform relatives about this potential risk and to promote studies on early prevention of oncological processes.  

One of the main limitations of the study is that it does not analyse the presence of risk factors for developing tumours such as obesity, smoking or contact with environmental toxins. The hypotheses supporting this cancer risk in infertility patients and their offspring could be due to inheritable genetic mutations, environmental risk factors or a combination of both.