Reacción a "Reactions: genomic evolution of lung cancer under scrutiny"

This research is of good quality and supported by solid data, as it uses part of the genomic sequence of the tumour cell population. It also has a large cohort of patients. In view of the fact that this is a very heterogeneous and divergent disease, the findings described here may represent a breakthrough in the field. 

It shows how genetic alterations accumulated during the development of the disease from the primary tumour can help determine the risk of dissemination and thus metastasis. These divergences could become a potential 'metastatic hallmark', predicting the risk of potential metastasis. 

However, it is important to consider that the application of the results of this study in clinical practice may be complex. In the case of lung cancer, which is the object of analysis, the authors agree that smoking is the determining factor in the incidence of the disease. Despite this, the results obtained are very promising and contribute to our knowledge of cancer development.