University of Málaga

Researchers in China have analysed data from more than 4,500 people and identified 13 proteins linked to brain ageing. In addition, changes in protein concentrations in the blood tend to peak at ages 57, 70 and 78. According to the authors, who publish the results in the journal Nature Aging, these ages may reflect transitions in human brain health at specific ages, and could therefore be important for designing possible interventions in the brain ageing process.

Vision loss and having high cholesterol - the so-called ‘bad’ cholesterol - are risk factors for developing dementia, according to a meta-analysis published in The Lancet. Eliminating these risk factors could reduce dementia cases by 2% and 7% respectively, the study says. Both factors are in addition to 12 others previously mentioned in a 2020 report such as less education, physical inactivity, hearing loss, excessive alcohol consumption, obesity or poor social contact, among others. According to the research, almost half of all dementia cases could be prevented or delayed if these risk factors were controlled.

Intimate partner violence is associated with an increased risk of depression and miscarriage, according to a systematic review of the scientific literature published since 1970. Sexual abuse in childhood is associated with an increased risk of alcohol use disorder and self-harm, says the study published in Nature Medicine. According to its authors, this analysis of 229 previous studies reveals that intimate partner violence and childhood sexual abuse have a more extensive impact on health than previously described.

A review of epidemiological data examines the physical and psychological complications that occur after childbirth in the medium and long term. More than a third of women reported lasting, and often neglected, health problems six weeks after childbirth. The most common complaints were: pain during sexual intercourse (35%), lower back pain (32%), urinary incontinence (8-31%), anxiety (9-24%), anal incontinence (19%), depression (11-17%) or significant fear of childbirth (6-15%). In their paper, published today in the journal The Lancet Global Health as part of a special series, the authors stress the importance of providing comprehensive health services beyond six weeks postpartum.

A study of more than 5,000 patients has developed a method to predict the biological age of our organs. They have analysed more than 4,000 proteins present in the blood and used machine learning models adapted to 11 different organs. According to the authors, almost 20 % of the population has accelerated organ ageing, which in many cases is associated with an increased risk of mortality of between 20 and 50 %. The results are published in the journal Nature.

Training people to get rid of unwanted thoughts can improve their mental health, according to a study from the University of Cambridge (UK). The research team stresses that these results "challenge the century-old wisdom" that trying to get rid of negative thoughts can have harmful effects on mental health. The study, published in Science Advances, involved 120 adults - some with major depression, anxiety and post-traumatic stress disorder - from 16 countries, who underwent a three-day online training to suppress certain thoughts. After the training, participants reported feeling less anxiety, negative emotions and symptoms of depression.

Seven studies published in Nature and Nature Medicine look at how lung cancer evolves, with genomic studies of more than 1,600 tumour samples taken from 421 patients in the TRACERx project. The research includes the most common type of lung cancer (NSCLC) and assesses why tumours sometimes recur, spread to other parts of the body or the effects of platinum-based chemotherapy.

Scientists have analysed data on 7.1 million common DNA variants (alterations in the standard sequence) in people with and without Alzheimer's disease. The results, published in PLOS Genetics, have helped them to develop a method that can predict the risk of suffering from this neurodegenerative disease, depending on the DNA variants that a person has and before presenting symptoms.

A study published in PLoS ONE concludes that students who attend classes with peers with disabilities do not see their academic results affected.