gynaecology

A US study analysed data from more than 110,000 women since 1993 and found that those with a history of endometriosis had a 31% higher risk of premature death (before the age of 70). In absolute terms, the rate of premature death in women with and without endometriosis was 2 and 1.4 per 1,000 person-years, respectively. In contrast, the presence of uterine fibroids was not associated with an overall increased risk, although the risk of death from gynaecological tumours was increased. The results are published in The BMJ.

Several studies have linked endometriosis to an increased risk of developing ovarian cancer. New research conducted in the United States on nearly half a million women has confirmed this association. Although the absolute risk remains low, the overall likelihood is four times higher than in the general population. However, the risk is higher when the endometriosis is of the infiltrative type or when an endometrioma develops in the ovary. The authors, who publish their results in the journal JAMA, raise the possibility of screening these women, because "precision medicine is more than just genetics".

Hormonal therapy to treat breast cancer is associated with a lower risk of Alzheimer's disease and dementia in women over 65, a study says. The retrospective analysis is based on data from more than 18,000 women with breast cancer in the US: two-thirds of them had received hormone therapy and one-third had not. The "protective effect" of hormone therapy declines with age and varies by ethnicity, adds the article published in JAMA Network Open. 

Artemisinins, plant-based antimalarials, may serve as a treatment for polycystic ovary syndrome - which affects millions of women worldwide and can lead to infertility - according to a new study published in Science. The compounds suppressed ovarian androgen production in rodents, as well as in a small cohort of 19 human patients for 12 weeks, leading to more regular menstrual cycles without side effects. 

Research published in JAMA Network Open indicates that women with premenstrual disorders diagnosed before the age of 25 have a higher risk of all-cause mortality and death by suicide. For death by suicide, the risk increased regardless of age at diagnosis. However, in general, women with premenstrual disorders do not have an increased risk of premature death from natural and unnatural causes. The study compares over several years a group of more than 67,000 women in Sweden with a diagnosed disorder with a group of more than 338,000 women without such a diagnosis. 

The ovarian cycle is regulated by internal circadian rhythms rather than external processes, says a study published in Science Advances. Using menstrual cycle data from some 3,000 women in Europe and North America, the authors add that the influence of the lunar cycle on women's menstrual cycle is weak, but significant.

The menopause should be tackled not just by treating specific symptoms, but more broadly, argue a group of researchers in an article published in The Lancet, one of a series on the subject. A medicalised approach can disempower women and lead to overtreatment, the authors warn. "Instead of focusing on menopause as an endocrine deficiency, we propose an empowerment model", they say. This model would incorporate the influence of psychological, social, and contextual factors that can be modified, and would also value the patient as the expert on her own condition.

At an informative meeting organized by the Science Media Centre Spain, the coauthor of a paper published this week in the journal Cell discussed his findings with journalists. Although the study was conducted with mice, he is confident in being able to analyze human eggs to see if his conclusions could explain the loss of fertility that occurs in women with age.

An international team, led by a Spanish group, has published the mechanism that allows immature egg reserves (oocytes) to survive for many years, up to almost half a century in the case of humans. The research studies how oocytes are affected by protein aggregates similar to those that damage other cells such as neurons and can cause neurodegenerative diseases such as Alzheimer's disease. The finding of how these egg reserves are kept healthy may help to understand some causes of infertility. The results are published in the journal Cell.

Women who follow vegan diets during pregnancy may have an increased risk of developing preeclampsia and giving birth to underweight newborns, suggests an observational study published in Acta Obstetricia et Gynecologica Scandinavica. In the investigation, more than 65,000 women identified themselves as omnivores, more than 800 as vegetarians -in some of their different modalities- and 18 as vegans.